C₄₈H₈₄O₈Si₃

Base Information

• Chemical Name: C₄₈H₈₄O₈Si₃
• CAS No.: 1351305-67-3
• Molecular Formula: C₄₈H₈₄O₈Si₃
• Molecular Weight: 873.447

Synonyms:C₄₈H₈₄O₈Si₃

Chemical Property of C₄₈H₈₄O₈Si₃

Chemical Property:

Purity/Quality:

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Technology Process of C₄₈H₈₄O₈Si₃

There total 18 articles about C₄₈H₈₄O₈Si₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-1-buten-4-ol (763-32-6) → C48H84O8Si3 (1351305-67-3)

Guidance literature:

Multi-step reaction with 15 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere; Reflux

2.1: asymmetric dihydroxylation-mix-α; hydroquinidein 1,4-phthalazinediyl diether / water; tert-butyl alcohol / 24 h / 0 °C / Inert atmosphere

3.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0.75 h / 0 °C / Inert atmosphere

3.2: 0.5 h / 0 - 20 °C / Inert atmosphere

4.1: magnesium; mercury dichloride / diethyl ether; toluene / 0 - 10 °C / Inert atmosphere

4.2: 1 h / 0 - 20 °C / Inert atmosphere

5.1: methylmagnesium bromide / tetrahydrofuran; diethyl ether / 6 h / 70 °C / Inert atmosphere

5.2: 5 h / 75 °C / Inert atmosphere

6.1: ammonium cerium (IV) nitrate / water; acetonitrile / 0.5 h / 0 - 20 °C / Inert atmosphere

7.1: sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide / dichloromethane; water / 0.5 h / 0 °C / Inert atmosphere

8.1: ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-bis(diphenylmethoxy))cyclopentadienyl-chlorotitanium / tetrahydrofuran; diethyl ether / 2 h / -78 - 0 °C / Inert atmosphere

8.2: 5 h / -78 °C / Inert atmosphere

9.1: toluene-4-sulfonic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

10.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 72 h / Inert atmosphere; Reflux

11.1: copper(l) iodide; tri-n-butyl-tin hydride; lithium chloride / tetrahydrofuran / 4 h / -40 - 0 °C / Inert atmosphere

12.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 2 h / pH 7.2 / aq. phosphate buffer; Inert atmosphere

13.1: tetramethylammonium triacetoxyborohydride / acetic acid; acetonitrile / 20 h / -30 °C / Inert atmosphere

14.1: 1H-imidazole / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

15.1: toluene / Reflux; Inert atmosphere

With 1H-imidazole; sodium hypochlorite; copper(l) iodide; Hoveyda-Grubbs catalyst second generation; ammonium cerium (IV) nitrate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; di-isopropyl azodicarboxylate; ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-bis(diphenylmethoxy))cyclopentadienyl-chlorotitanium; asymmetric dihydroxylation-mix-α; methylmagnesium bromide; tri-n-butyl-tin hydride; toluene-4-sulfonic acid; magnesium; methanesulfonyl chloride; hydroquinidein 1,4-phthalazinediyl diether; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium chloride; mercury dichloride; potassium bromide; tetramethylammonium triacetoxyborohydride; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetic acid; toluene; acetonitrile; tert-butyl alcohol; 1.1: Mitsunobu reaction / 2.1: Sharpless dihydroxylation;

DOI:10.1021/ol203064r

Reference yield:

6-[2-hydroxyhex-5-en-1-yl]-2,2-dimethyl-2,4-dihydro-1,3-dioxin-4-one → C48H84O8Si3 (1351305-67-3)

Guidance literature:

Multi-step reaction with 8 steps

1: tert.-butylhydroperoxide; selenium(IV) oxide / decane; dichloromethane / 24 h / 20 °C / Inert atmosphere; Reflux

2: manganese(IV) oxide / dichloromethane / 4 h / Inert atmosphere; Reflux

3: Hoveyda-Grubbs catalyst second generation / dichloromethane / 72 h / Inert atmosphere; Reflux

4: copper(l) iodide; tri-n-butyl-tin hydride; lithium chloride / tetrahydrofuran / 4 h / -40 - 0 °C / Inert atmosphere

5: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 2 h / pH 7.2 / aq. phosphate buffer; Inert atmosphere

6: tetramethylammonium triacetoxyborohydride / acetic acid; acetonitrile / 20 h / -30 °C / Inert atmosphere

7: 1H-imidazole / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

8: toluene / Reflux; Inert atmosphere

With 1H-imidazole; tert.-butylhydroperoxide; manganese(IV) oxide; selenium(IV) oxide; copper(l) iodide; Hoveyda-Grubbs catalyst second generation; tri-n-butyl-tin hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium chloride; tetramethylammonium triacetoxyborohydride; In tetrahydrofuran; decane; dichloromethane; acetic acid; toluene; acetonitrile;

DOI:10.1021/ol203064r

Reference yield:

6-[(2S)-2-hydroxy-4-oxohex-5-en-1-yl]-2,2-dimethyl-2,4-dihydro-1,3-dioxin-4-one (1031239-13-0) → C48H84O8Si3 (1351305-67-3)

Guidance literature:

Multi-step reaction with 6 steps

1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 72 h / Inert atmosphere; Reflux

2: copper(l) iodide; tri-n-butyl-tin hydride; lithium chloride / tetrahydrofuran / 4 h / -40 - 0 °C / Inert atmosphere

3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 2 h / pH 7.2 / aq. phosphate buffer; Inert atmosphere

4: tetramethylammonium triacetoxyborohydride / acetic acid; acetonitrile / 20 h / -30 °C / Inert atmosphere

5: 1H-imidazole / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

6: toluene / Reflux; Inert atmosphere

With 1H-imidazole; copper(l) iodide; Hoveyda-Grubbs catalyst second generation; tri-n-butyl-tin hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium chloride; tetramethylammonium triacetoxyborohydride; In tetrahydrofuran; dichloromethane; acetic acid; toluene; acetonitrile;

DOI:10.1021/ol203064r

upstream raw materials:

2-methyl-1-buten-4-ol

6-[(2S)-2-hydroxy-4-oxohex-5-en-1-yl]-2,2-dimethyl-2,4-dihydro-1,3-dioxin-4-one

(3R)-1-(4-methoxyphenoxy)-3-methylhept-6-yn-3-ol

(3R)-3-hydroxy-3-methyl-7-[tris(propan-2-yl)silyl]hept-6-ynal

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