Technology Process of (3R)-1-(4-methoxyphenoxy)-3-methylhept-6-yn-3-ol
There total 5 articles about (3R)-1-(4-methoxyphenoxy)-3-methylhept-6-yn-3-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
propargyl bromide;
With
magnesium; mercury dichloride;
In
diethyl ether; toluene;
at 0 - 10 ℃;
Inert atmosphere;
(2S)-2-[2-(4-methoxyphenoxy)ethyl]-2-methyloxirane;
In
diethyl ether; toluene;
at 0 - 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/ol203064r
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere; Reflux
2.1: asymmetric dihydroxylation-mix-α; hydroquinidein 1,4-phthalazinediyl diether / water; tert-butyl alcohol / 24 h / 0 °C / Inert atmosphere
3.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0.75 h / 0 °C / Inert atmosphere
3.2: 0.5 h / 0 - 20 °C / Inert atmosphere
4.1: magnesium; mercury dichloride / diethyl ether; toluene / 0 - 10 °C / Inert atmosphere
4.2: 1 h / 0 - 20 °C / Inert atmosphere
With
di-isopropyl azodicarboxylate; asymmetric dihydroxylation-mix-α; magnesium; methanesulfonyl chloride; hydroquinidein 1,4-phthalazinediyl diether; triethylamine; triphenylphosphine; mercury dichloride;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; toluene; tert-butyl alcohol;
1.1: Mitsunobu reaction / 2.1: Sharpless dihydroxylation;
DOI:10.1021/ol203064r
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere; Reflux
2.1: asymmetric dihydroxylation-mix-α; hydroquinidein 1,4-phthalazinediyl diether / water; tert-butyl alcohol / 24 h / 0 °C / Inert atmosphere
3.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0.75 h / 0 °C / Inert atmosphere
3.2: 0.5 h / 0 - 20 °C / Inert atmosphere
4.1: magnesium; mercury dichloride / diethyl ether; toluene / 0 - 10 °C / Inert atmosphere
4.2: 1 h / 0 - 20 °C / Inert atmosphere
With
di-isopropyl azodicarboxylate; asymmetric dihydroxylation-mix-α; magnesium; methanesulfonyl chloride; hydroquinidein 1,4-phthalazinediyl diether; triethylamine; triphenylphosphine; mercury dichloride;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; toluene; tert-butyl alcohol;
1.1: Mitsunobu reaction / 2.1: Sharpless dihydroxylation;
DOI:10.1021/ol203064r
