5-bromo-6-(4-fluorophenyl)-8-methoxy-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one

Base Information

Chemical Name:5-bromo-6-(4-fluorophenyl)-8-methoxy-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one
CAS No.:1616829-37-8
Molecular Formula:C₂₁H₂₄BrFN₂O₃Si
Molecular Weight:479.421
Hs Code.:

Synonyms:5-bromo-6-(4-fluorophenyl)-8-methoxy-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one

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Chemical Property of 5-bromo-6-(4-fluorophenyl)-8-methoxy-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one

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Technology Process of 5-bromo-6-(4-fluorophenyl)-8-methoxy-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one

There total 4 articles about 5-bromo-6-(4-fluorophenyl)-8-methoxy-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1616829-36-7
6-(4-fluorophenyl)-8-methoxy-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one

: 1616829-37-8
5-bromo-6-(4-fluorophenyl)-8-methoxy-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one

Guidance literature:: With silver(II) sulfate; bromine; In acetic acid; at 20 ℃; for 16h;

Reference yield:

: 1616829-35-6
6-bromo-8-methoxy-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one

: 1616829-37-8
5-bromo-6-(4-fluorophenyl)-8-methoxy-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane / 3 h / 90 °C

2: bromine; silver(II) sulfate / acetic acid / 16 h / 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; silver(II) sulfate; bromine; potassium carbonate; In 1,4-dioxane; acetic acid;

Reference yield:

: 1215634-37-9
4-bromo-2-carboxy-6-methoxybenzenamine hydrobromide

: 1616829-37-8
5-bromo-6-(4-fluorophenyl)-8-methoxy-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 12 h / 150 °C

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1.5 h / 60 °C

2.2: 72 h / 20 °C / Cooling with ice

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane / 3 h / 90 °C

4.1: bromine; silver(II) sulfate / acetic acid / 16 h / 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; silver(II) sulfate; bromine; sodium hydride; potassium carbonate; In 1,4-dioxane; acetic acid; N,N-dimethyl-formamide; mineral oil;