3-(bis((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amino)propan-1-ol

Base Information

• Chemical Name: 3-(bis((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amino)propan-1-ol
• CAS No.: 1595288-50-8
• Molecular Formula: C₂₃H₂₇N₇O
• Molecular Weight: 417.514
• Mol file: 1595288-50-8.mol

Synonyms:3-(bis((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amino)propan-1-ol

Chemical Property of 3-(bis((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amino)propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(bis((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amino)propan-1-ol

There total 2 articles about 3-(bis((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amino)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

3-(di(prop-2-yn-1-yl)amino)propan-1-ol (1207095-52-0) + benzyl azide (622-79-7) → 3-(bis((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amino)propan-1-ol (1595288-50-8)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; for 14h;

DOI:10.1002/anie.201310671

Reference yield:

benzyl bromide (100-39-0) → 3-(bis((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amino)propan-1-ol (1595288-50-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide / water; acetone / 20 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 14 h

With sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; acetone; tert-butyl alcohol;

DOI:10.1002/anie.201310671

Reference yield: 75.0%

3-(bis((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amino)propan-1-ol (1595288-50-8) → 3-azido-N,N-bis((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)propan-1-amine (1595288-45-1)

Guidance literature:

3-(bis((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amino)propan-1-ol; With methanesulfonyl chloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

With sodium azide; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1002/anie.201310671

upstream raw materials:

3-(di(prop-2-yn-1-yl)amino)propan-1-ol

benzyl azide

benzyl bromide

Downstream raw materials:

3-azido-N,N-bis((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)propan-1-amine

7-(1-(3-(bis((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amino)propyl)-1H-1,2,3-triazol-4-yl)-2H-chromen-2-one