3-(2-Methoxy-6-nitro-phenyl)-2-oxo-propionic acid ethyl ester

Base Information

• Chemical Name: 3-(2-Methoxy-6-nitro-phenyl)-2-oxo-propionic acid ethyl ester
• CAS No.: 301155-92-0
• Molecular Formula: C₁₂H₁₃NO₆
• Molecular Weight: 267.238
• Mol file: 301155-92-0.mol

Synonyms:3-(2-Methoxy-6-nitro-phenyl)-2-oxo-propionic acid ethyl ester

Chemical Property of 3-(2-Methoxy-6-nitro-phenyl)-2-oxo-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-Methoxy-6-nitro-phenyl)-2-oxo-propionic acid ethyl ester

There total 1 articles about 3-(2-Methoxy-6-nitro-phenyl)-2-oxo-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

6-methoxy-2-nitrotoluene (4837-88-1) + oxalic acid diethyl ester (95-92-1) → 3-(2-Methoxy-6-nitro-phenyl)-2-oxo-propionic acid ethyl ester (301155-92-0)

Guidance literature:

With potassium tert-butylate; In diethyl ether; at 20 ℃;

Reference yield:

3-(2-Methoxy-6-nitro-phenyl)-2-oxo-propionic acid ethyl ester (301155-92-0) → pyruvic acid (4837-89-2)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/jm00400a009

Reference yield:

3-(2-Methoxy-6-nitro-phenyl)-2-oxo-propionic acid ethyl ester (301155-92-0) → 4-methoxy-1H-indole-2-carboxylic acid (103260-65-7)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. HCl

2: FeSO₄/NH₃

With hydrogenchloride; ammonia; iron(II) sulfate;

DOI:10.1021/jm00400a009

upstream raw materials:

6-methoxy-2-nitrotoluene

oxalic acid diethyl ester

Downstream raw materials:

pyruvic acid

ethyl 4-methoxy-indole-2-carboxylate

4-methoxy-1H-indole-2-carboxylic acid

methyl 4-methoxy-1H-indole-2-carboxylate