103260-65-7

Usage

Uses

Used in Pharmaceutical Research:
4-Methoxy-1H-indole-2-carboxylic acid is used as a building block for the synthesis of various pharmaceutical compounds due to its versatile chemical properties and potential biological activities.
Used in Organic Synthesis:
In the field of organic synthesis, 4-Methoxy-1H-indole-2-carboxylic acid is used as a key intermediate for the preparation of a wide range of organic compounds, leveraging its reactivity and structural features.
Used in Drug Development:
4-Methoxy-1H-indole-2-carboxylic acid is employed as a precursor in the development of new drugs, capitalizing on its anti-inflammatory and antioxidant properties to create therapeutic agents for various medical conditions.
Used in Bioactive Molecule Design:
4-Methoxy-1H-indole-2-carboxylic acid is utilized in the design of bioactive molecules, where its indole core and functional groups can be modified to enhance or introduce specific biological activities, such as targeting particular receptors or enzymes in the body.

InChI:InChI=1/C10H9NO3/c1-14-9-4-2-3-7-6(9)5-8(11-7)10(12)13/h2-5,11H,1H3,(H,12,13)

Upstream product

• 111258-23-2 methyl 4-methoxy-1H-indole-2-carboxylate 
• 4837-88-1 6-methoxy-2-nitrotoluene 
• 301155-92-0 3-(2-Methoxy-6-nitro-phenyl)-2-oxo-propionic acid ethyl ester 
• 135-02-4 ortho-anisaldehyde 
• 143702-35-6 (Z)-2-azido-3-(2-methoxyphenyl)acrylic acid methyl ester 
• 4837-89-2 pyruvic acid 

Downstream Products

• 43142-25-2 ethyl 4-methoxy-indole-2-carboxylate 
• 4837-90-5 4-methoxy-1H-indole 
• 90734-97-7 4-methoxyindole-3-carboxaldehyde 
• 651331-49-6 4-methoxy-1-(4-methoxybenzenesulfonyl)-1H-indole-3-carbaldehyde 
• 651331-65-6 10-[4-methoxy-1-(4-methoxybenzenesulfonyl)-1H-indol-3-yl]decan-1-ol 
• 651331-68-9 12-[4-methoxy-1-(4-methoxybenzsulfonyl)-1H-indole-3-yl]-dodecane-1-ol 
• 651331-69-0 14-[4-methoxy-1-(4-methoxybenzsulfonyl)-1H-indole-3-yl]-tetradecane-1-ol 
• 651331-70-3 16-[4-methoxy-1-(4-methoxybenzsulfonyl)-1H-indole-3-yl]-hexadecane-1-ol 
• 651331-71-4 18-[4-methoxy-1-(4-methoxybenzsulfonyl)-1H-indole-3-yl]-octadecane-1-ol 
• 138863-11-3 1-[4-Methoxyindolyl-2-carbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl]piperazine 
• 1210357-88-2 C₂₂H₂₃N₃O₆ 
• 870153-29-0 PF-00835231 
• 870153-29-0 N-[(1R)-1-[[(1S)-3-hydroxy-2-oxo-1-[[(3S)-2-oxopyrrolidin-3-yl]methyl]propyl]carbamoyl]-3-methyl-butyl]-4-methoxy-1H-indole-2-carboxamide 

Relevant academic research and scientific papers

AMINOPYRROLIDINES AS CHEMOKINE RECEPTOR ANTAGONISTS

The present invention is directed to novel aminopyrrolidines of formula I, pharmaceutically acceptable salts thereof, metabolites thereof, isomers thereof, stereoisomers thereof or pro-drugs thereof, wherein the variables are as defined herein. The compou

ACETYLENE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE

The present invention is directed to certain hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed.

INDOLE DERIVATIVES AND DRUGS CONTAINING THE SAME

An indole derivative represented by the following general formula (1) : wherein at least one of R1, R2, R3, and R4 represents an alkoxy group containing 1 to 20 carbon atoms, and other groups of the R1, R2, R3, and R4 represent hydrogen, an alkyl group containing 1 to 6 carbon atoms, acetyl group, or hydroxyl group; and either one of X and Y represents -(CH2)nOH wherein n is an integer of 0 to 30, and the other one of the X and Y represents hydrogen atom; or a salt thereof; and a drug and an agent for promoting differentiation of a stem cell containing such indole derivative or its salt as an effective component. The indole derivative (1) of the present invention has action of inducing differentiation of neural stem cell specifically into a neuron, and this indole derivative is useful as a prophylactic or therapeutic drug for brain dysfunction or neuropathy caused by loss or degeneration of the neuron.

Effects of indole fatty alcohols on the differentiation of neural stem cell derived neurospheres

In a search for inducers of neuronal differentiation to treat neurodegenerative diseases such as Alzheimer's disease, a series of indole fatty alcohols (IFAs) were prepared, 13c (n = 18) was able to promote the differentiation of neural stem cell derived neurospheres into neurons at a concentration of 10 nM. Analysis of the expression of the Notch pathway genes in neurospheres treated during the differentiation phase with 13c (n = 18) revealed a significant decrease in the transcription of the Notch 4 receptor.

The design, synthesis and activity of non-ATP competitive inhibitors of pp60(c-src) tyrosine kinase. Part 2: Hydroxyindole derivatives

As part of continuing effort to identify novel scaffolds that inhibit the pp60(c-src) protein tyrosine kinase, a series of hydroxyindole amides was rationally designed and synthesized. The most potent derivative was found to bind non-competitively with respect to ATP. (C) 2000 Elsevier Science Ltd. All rights reserved.

2-[N-acylamino(C1-C3)alkyl]indoles as MT1 melatonin receptor partial agonists, antagonists, and putative inverse agonists

The synthesis of several novel indole melatonin analogues substituted at the 2-position with acylaminomethyl (8-11), acylaminoethyl (5a-k), or acylaminopropyl (13) side chains is reported. On the basis of a novel in vitro functional assay (specific bindin

Anti-aids piperazines

The present invention includes diaromatic substituted heterocyclic compounds (III) STR1 which are useful in treating individuals infected with the HIV virus. The invention includes certain previously generically disclosed anti-AIDS piperazinyl compounds (V) and a method of treating HIV infected individuals with the indoles of formula (V) and the anti-AIDS amines (X).

Indoline Analogues of Idazoxan: Potent α2-Antagonists and α1-Agonists

The synthesis and α-adrenergic activity of a series of substituted 2-imidazolinylindolines are described.Substitution in the indoline ring generated compounds with a spectrum of adrenoceptor antagonist/agonist profiles that proved sensitive to both the nature and position of the substituent.Many of the derivatives possess greater presynaptic antagonist potency that the corresponding benzodioxan 1, dihydrobenzofuran 2, and indan 3 analogues; however, this α2-antagonism is often accompanied by α1-agonist activity.It was not possible to separate α2-antagonist from α1-agonist properties in this series.Compounds of most interest proved to be the N-ethyl 6, 5-chloro-N-methyl 18 and 5-chloro-N-ethyl 23 derivatives, all being potent α2-antagonists and α1-agonists.Substitution at the 4- and 7-position of the indoline ring generally gave compounds with nonselective agonist properties.