2-(4-Hydroxyphenoxy)-2-methylpropionic acid ethyl ester

Base Information

• Chemical Name: 2-(4-Hydroxyphenoxy)-2-methylpropionic acid ethyl ester
• CAS No.: 42806-90-6
• Molecular Formula: C12H16O4
• Molecular Weight: 224.257
• Hs Code.: 2918990090
• Mol file: 42806-90-6.mol

Synonyms:

Chemical Property of 2-(4-Hydroxyphenoxy)-2-methylpropionic acid ethyl ester

Chemical Property:

• Vapor Pressure: 6.29E-05mmHg at 25°C
• Boiling Point: 335.1°C at 760 mmHg
• Flash Point: 123.8°C
• PSA: 55.76000
• Density: 1.132g/cm³
• LogP: 2.11270

Purity/Quality:

99%min ^*data from raw suppliers

Ethyl 2-(4-hydroxyphenoxy)-2-methylpropanoate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-Hydroxyphenoxy)-2-methylpropionic acid ethyl ester

There total 5 articles about 2-(4-Hydroxyphenoxy)-2-methylpropionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyl 2-(4-(benzyloxy)phenoxy)-2-methylpropanoate (19587-96-3) → 2-(4-hydroxyphenoxy)-2-methyl propionic acid ethyl ester (42806-90-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; at 20 ℃;

Reference yield: 70.1%

ethyl 2-bromoisobutyrate (600-00-0) + hydroquinone (123-31-9,8027-02-9) → 2-(4-hydroxyphenoxy)-2-methyl propionic acid ethyl ester (42806-90-6)

Guidance literature:

hydroquinone; With sodium hydride; In dimethyl sulfoxide; at 80 ℃; for 2h;

ethyl 2-bromoisobutyrate;

Reference yield: 23.0%

ethyl 2-bromoisobutyrate (600-00-0) + hydroquinone (123-31-9,8027-02-9) → 2-(4-hydroxyphenoxy)-2-methyl propionic acid ethyl ester (42806-90-6) + 2,2'-(4-Phenylen-dioxi)-bis-(2-methyl-propionsaeure-ethylester) (122353-26-8)

Guidance literature:

With potassium carbonate; In acetonitrile; for 20h; Heating;

DOI:10.1002/ardp.19893220603

upstream raw materials:

ethyl 2-bromoisobutyrate

hydroquinone

ethyl 2-(4-(benzyloxy)phenoxy)-2-methylpropanoate

4-Benzyloxyphenol

Downstream raw materials:

2-(4-Hydroxyphenoxy)-2-methyl-propionic acid

2-methyl-2-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenoxy}propionic acid ethyl ester

2-(4-{2-[2-(4-bromophenyl)-5-methyloxazol-4-yl]ethoxy}phenoxy)-2-methylpropionic acid ethyl ester

2-{4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid ethyl ester

Refernces

• 1、 Giampietro, Letizia,Laghezza, Antonio,Cerchia, Carmen,Florio, Rosalba,Recinella, Lucia,Capone, Fabio,Ammazzalorso, Alessandra,Bruno, Isabella,De Filippis, Barbara,Fantacuzzi, Marialuigia,Ferrante, Claudio,MacCallini, Cristina,Tortorella, Paolo,Verginelli, Fabio,Brunetti, Luigi,Cama, Alessandro,Amoroso, Rosa,Loiodice, Fulvio,Lavecchia, Antonio. "Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome". . p. 545 - 551. Retrieved 2019/03/19.
• 2、 -. "PPAR AGONIST COMPOUNDS, PREPARATION AND USES". Page/Page column 12; 20. . Retrieved 2011/08/22.