2-{4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid ethyl ester

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Chemical Name:2-{4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid ethyl ester
CAS No.:328918-88-3
Molecular Formula:C₃₀H₃₁NO₅
Molecular Weight:485.58
Hs Code.:

Synonyms:2-{4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid ethyl ester

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Chemical Property of 2-{4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid ethyl ester

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Technology Process of 2-{4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid ethyl ester

There total 9 articles about 2-{4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 42806-90-6
2-(4-hydroxyphenoxy)-2-methyl propionic acid ethyl ester

: 328918-86-1
toluene-4-sulfonic acid 2-(2-biphenyl-4-yl-5-methyloxazol-4-yl)ethyl ester

: 328918-88-3
2-{4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid ethyl ester

Guidance literature:: With caesium carbonate; phenol; In N,N-dimethyl-formamide; at 55 ℃; for 18h;
DOI:10.1021/jm0155188

Reference yield: 47.0%

: 328918-88-3
2-{4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid ethyl ester

Guidance literature:

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 328918-88-3
2-{4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 74 percent / aq. HCl; AcOH / 0.58 h / 0 °C

2: 72 percent / POCl₃ / CHCl₃ / 0.5 h / Heating

3: 100 percent / KI / dimethylformamide / 3.5 h / 85 °C

4: 60 percent / KOH / 2-methoxy-ethanol; H₂O / 3 h / Heating

5: 72 percent / borane-THF / tetrahydrofuran / 2 h / 20 °C

6: 97 percent / Pd(OAc)2; PPh₃; Na₂CO₃ / propan-1-ol; H₂O / 1.5 h / Heating

7: pyridine; DMAP / CH₂Cl₂ / 0.5 h / 32 °C

8: 47 percent / Cs₂CO₃; phenol / dimethylformamide / 18 h / 55 °C

With pyridine; hydrogenchloride; dmap; palladium diacetate; potassium hydroxide; borane-THF; sodium carbonate; caesium carbonate; acetic acid; triphenylphosphine; potassium iodide; trichlorophosphate; phenol; In tetrahydrofuran; propan-1-ol; dichloromethane; chloroform; 2-methoxy-ethanol; water; N,N-dimethyl-formamide; 6: Suzuki coupling;
DOI:10.1021/jm0155188