N-(5-formyl-1H-pyrrole-2-carbonyl)-L-phenylalanyl-L-leucine methyl ester

Base Information

Chemical Name:N-(5-formyl-1H-pyrrole-2-carbonyl)-L-phenylalanyl-L-leucine methyl ester
CAS No.:635313-73-4
Molecular Formula:C₂₂H₂₇N₃O₅
Molecular Weight:413.473
Hs Code.:

Synonyms:N-(5-formyl-1H-pyrrole-2-carbonyl)-L-phenylalanyl-L-leucine methyl ester

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Chemical Property of N-(5-formyl-1H-pyrrole-2-carbonyl)-L-phenylalanyl-L-leucine methyl ester

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Technology Process of N-(5-formyl-1H-pyrrole-2-carbonyl)-L-phenylalanyl-L-leucine methyl ester

There total 3 articles about N-(5-formyl-1H-pyrrole-2-carbonyl)-L-phenylalanyl-L-leucine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 7126-51-4
5-formyl-1H-pyrrole-2-carboxylic acid

: 38155-19-0
L-phenylalanyl-L-leucine methyl ester

: 635313-73-4
N-(5-formyl-1H-pyrrole-2-carbonyl)-L-phenylalanyl-L-leucine methyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1039/b302411c

Reference yield:

: 7126-50-3
ethyl 5-formyl-1H-pyrrole-2-carboxylate

: 635313-73-4
N-(5-formyl-1H-pyrrole-2-carbonyl)-L-phenylalanyl-L-leucine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / aq. KOH / 2 h / 40 - 50 °C

2: 52 percent / BOP; i-Pr₂NEt / CH₂Cl₂ / 16 h / 20 °C

With potassium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1039/b302411c

Reference yield:

: 2199-43-1
ethyl 1H-pyrrole-2-carboxylate

: 635313-73-4
N-(5-formyl-1H-pyrrole-2-carbonyl)-L-phenylalanyl-L-leucine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 61 percent / POCl₃ / 1,2-dichloro-ethane / 0.25 h / Heating

2: 60 percent / aq. KOH / 2 h / 40 - 50 °C

3: 52 percent / BOP; i-Pr₂NEt / CH₂Cl₂ / 16 h / 20 °C

With potassium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1039/b302411c