2-Amino-6,7-dihydro-7-phenylcyclopent[e]-1,3-oxazin-4(5H)-one

Base Information

Chemical Name:2-Amino-6,7-dihydro-7-phenylcyclopent[e]-1,3-oxazin-4(5H)-one
CAS No.:312312-81-5
Molecular Formula:C₁₃H₁₂N₂O₂
Molecular Weight:228.25
Hs Code.:
DSSTox Substance ID:DTXSID701182020
Nikkaji Number:J1.377.804C

Synonyms:SCHEMBL369220;MNBOGFLTAOTOJM-UHFFFAOYSA-N;DTXSID701182020;2-Amino-6,7-dihydro-7-phenylcyclopent[e]-1,3-oxazin-4(5H)-one;2-Amino-7-phenyl-6,7-dihydrocyclopenta[e]-1,3-oxazine-4(5H)-one;2-amino-7-phenyl-6,7-dihydrocyclopenta[e][1,3]oxazin-4 (5H)-one;2-amino-7-phenyl-6,7-dihydrocyclopenta[e][1,3]oxazin-4(5H)-one;312312-81-5

Suppliers and Price of 2-Amino-6,7-dihydro-7-phenylcyclopent[e]-1,3-oxazin-4(5H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Amino-6,7-dihydro-7-phenylcyclopent[e]-1,3-oxazin-4(5H)-one

Chemical Property:

XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:228.089877630
Heavy Atom Count:17
Complexity:406

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC2=C(C1C3=CC=CC=C3)OC(=NC2=O)N

Technology Process of 2-Amino-6,7-dihydro-7-phenylcyclopent[e]-1,3-oxazin-4(5H)-one

There total 9 articles about 2-Amino-6,7-dihydro-7-phenylcyclopent[e]-1,3-oxazin-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.2%

: 867-44-7,147895-43-0
S-Methylisothiourea sulfate

: 312312-75-7
ethyl 3-phenyl-2-oxocyclopentane-1-carboxylate

: 312312-81-5
2-Amino-7-phenyl-6,7-dihydrocyclopenta[e][1,3]oxazin-4(5H)-one

Guidance literature:: With potassium hydroxide; In water; at 20 ℃;

Reference yield: 61.2%

: 147895-43-0
S-methylisothiourea hemisulphate

: 312312-75-7
ethyl 3-phenyl-2-oxocyclopentane-1-carboxylate

: 312312-81-5
2-Amino-7-phenyl-6,7-dihydrocyclopenta[e][1,3]oxazin-4(5H)-one

Guidance literature:: With potassium hydroxide; In water; at 20 ℃;

Reference yield:

: 120-92-3
cyclopentanone

: 312312-81-5
2-Amino-7-phenyl-6,7-dihydrocyclopenta[e][1,3]oxazin-4(5H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: diethyl ether; tetrahydrofuran / 2.5 h / 0 °C / Reflux

2.1: formic acid; dihydrogen peroxide / 4 h / 20 - 40 °C

3.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C

3.2: 3 h / 25 °C

4.1: potassium hydroxide / water / 20 °C

With n-butyllithium; formic acid; dihydrogen peroxide; diisopropylamine; potassium hydroxide; In tetrahydrofuran; hexanes; diethyl ether; water;