Technology Process of (E,R)-[(2-methyldec-4-en-3-yloxy)methyl]benzene
There total 3 articles about (E,R)-[(2-methyldec-4-en-3-yloxy)methyl]benzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(E,R)-2-methyldec-4-en-3-ol;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 0.333333h;
Inert atmosphere;
benzyl bromide;
With
tetrabutylammomium bromide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 72h;
Inert atmosphere;
DOI:10.1021/ol102936z
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: (1S,2R)-(+)-N-methylephedrine; zinc trifluoromethanesulfonate; triethylamine / toluene / 12 h / 60 °C / Inert atmosphere
2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / diethyl ether / 72 h / 40 °C / Inert atmosphere
2.2: 1 h / 0 - 20 °C / Inert atmosphere
3.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere
3.2: 72 h / 20 °C / Inert atmosphere
With
(1S,2R)-(+)-N-methylephedrine; zinc trifluoromethanesulfonate; sodium hydride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
diethyl ether; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol102936z
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / diethyl ether / 72 h / 40 °C / Inert atmosphere
1.2: 1 h / 0 - 20 °C / Inert atmosphere
2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere
2.2: 72 h / 20 °C / Inert atmosphere
With
sodium hydride; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/ol102936z
