N-((S)-1-(4-((R)-1-(4-(3-methoxypropoxy)phenyl)pyrrolidin-3-yloxy)phenyl)ethyl)-acetamide

Base Information

Chemical Name:N-((S)-1-(4-((R)-1-(4-(3-methoxypropoxy)phenyl)pyrrolidin-3-yloxy)phenyl)ethyl)-acetamide
CAS No.:1594129-37-9
Molecular Formula:C₂₄H₃₂N₂O₄
Molecular Weight:412.529
Hs Code.:

Synonyms:N-((S)-1-(4-((R)-1-(4-(3-methoxypropoxy)phenyl)pyrrolidin-3-yloxy)phenyl)ethyl)-acetamide

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Chemical Property of N-((S)-1-(4-((R)-1-(4-(3-methoxypropoxy)phenyl)pyrrolidin-3-yloxy)phenyl)ethyl)-acetamide

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Technology Process of N-((S)-1-(4-((R)-1-(4-(3-methoxypropoxy)phenyl)pyrrolidin-3-yloxy)phenyl)ethyl)-acetamide

There total 8 articles about N-((S)-1-(4-((R)-1-(4-(3-methoxypropoxy)phenyl)pyrrolidin-3-yloxy)phenyl)ethyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 36865-41-5
3-bromopropanol methyl ether

: 1594130-93-4
((S)-1-(4-(((R)-1-(4-hydroxyphenyl)pyrrolidin-3-yl)oxy)phenyl)ethyl)acetamide

: 1594129-37-9
N-((S)-1-(4-((R)-1-(4-(3-methoxypropoxy)phenyl)pyrrolidin-3-yloxy)phenyl)ethyl)-acetamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 4h;

Reference yield:

: 1594129-41-5
C₂₇H₃₀N₂O₃

: 1594129-37-9
N-((S)-1-(4-((R)-1-(4-(3-methoxypropoxy)phenyl)pyrrolidin-3-yloxy)phenyl)ethyl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 1500.15 Torr

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 186296-23-1
(S)-N-(1-(4-bromophenyl)ethyl)acetamide

: 1594129-37-9
N-((S)-1-(4-((R)-1-(4-(3-methoxypropoxy)phenyl)pyrrolidin-3-yloxy)phenyl)ethyl)-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 3 h / 80 °C / Inert atmosphere

2: dihydrogen peroxide; sodium hydroxide / water; tetrahydrofuran / 2 h / 0 °C

3: caesium carbonate / N,N-dimethyl-formamide / 80 °C

4: hydrogenchloride / 1,4-dioxane / 20 °C

5: XPhos; palladium diacetate; caesium carbonate / toluene; tert-butyl alcohol / 120 °C / Inert atmosphere

6: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 1500.15 Torr

7: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; potassium acetate; palladium diacetate; potassium carbonate; caesium carbonate; sodium hydroxide; XPhos; In tetrahydrofuran; 1,4-dioxane; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;