1-Bromo-3-methoxypropane

Base Information

• Chemical Name: 1-Bromo-3-methoxypropane
• CAS No.: 36865-41-5
• Molecular Formula: C4H9BrO
• Molecular Weight: 153.019
• Hs Code.: 29033990
• European Community (EC) Number: 609-300-1
• DSSTox Substance ID: DTXSID00335324
• Wikidata: Q72446370
• Mol file: 36865-41-5.mol

Synonyms:1-Bromo-3-methoxypropane;36865-41-5;1,3-bromomethoxypropane;3-Bromo-1-methoxypropane;3-Bromopropyl Methyl Ether;Propane, 1-bromo-3-methoxy-;3-methoxypropylbromide;3-methoxypropyl bromide;3-methoxybromopropane;3-bromo-methoxypropane;3-bromopropylmethylether;3-methoxy-1-bromopropane;1-Methoxy-3-bromopropane;gamma-methoxypropyl bromide;1-bromo-3-methoxy propane;1-bromo-3-methoxy-propane;3-bromo-1-methoxy propane;SCHEMBL8171;1-bromanyl-3-methoxy-propane;1-bromo-3-(methyloxy)propane;DTXSID00335324;BBL101812;MFCD02258473;STL555609;1-Bromo-3-methoxypropane, AldrichCPR;AKOS005255555;CS-W010945;GS-3265;AM20090592;B3499;FT-0657681;EN300-157737;F11235;A823412;J-504428;F0001-1062

Chemical Property of 1-Bromo-3-methoxypropane

Chemical Property:

• Vapor Pressure: 37.2mmHg at 25°C
• Refractive Index: 1.439
• Boiling Point: 103.5 °C at 760 mmHg
• Flash Point: 30.6 °C
• PSA: 9.23000
• Density: 1.341 g/cm³
• LogP: 1.41780
• Storage Temp.: Store below +30°C.
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 151.98368
• Heavy Atom Count: 6
• Complexity: 23.5

Purity/Quality:

99% ^*data from raw suppliers

1-Bromo-3-methoxypropane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCCBr

Technology Process of 1-Bromo-3-methoxypropane

There total 6 articles about 1-Bromo-3-methoxypropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

trimethoxonium tetrafluoroborate (420-37-1) + 1-bromo-3-propanol (627-18-9) → 3-bromopropanol methyl ether (36865-41-5)

Guidance literature:

In dichloromethane; 1.) reflux, 2.) K₂CO₃, water;

DOI:10.1002/hlca.19800630804

Reference yield: 51.0%

methoxypropanol (1589-49-7) → 3-bromopropanol methyl ether (36865-41-5)

Guidance literature:

With N-Bromosuccinimide; triphenylphosphine; at 25 ℃; for 16h;

DOI:10.1021/ja00368a024

Reference yield: 22.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 1-bromo-3-propanol (627-18-9) → 3-bromopropanol methyl ether (36865-41-5)

Guidance literature:

With boron trifluoride diethyl etherate; In diethyl ether; at -10 ℃;

upstream raw materials:

methoxypropanol

methanol

1,3-dibromo-propane

sodium methylate

Downstream raw materials:

1-(3-Methoxy-propyl)-cyclohexene

3-[4-(3-methoxy-propoxy)-phenyl]-3-phenyl-propionic acid ethyl ester

4-methoxy-3-(3-methoxy-propoxy)-benzoic acid methyl ester

C₂₂H₂₁BrClNO₅

Refernces

• 1、 -. "Indole derivatives as 5-HT1-like agonists". . . Retrieved 2008/06/13.
• 2、 Takeuchi, Hiroshi,Kishioka, Hiroaki,Kitajima, Kunio. "EFFICIENT AND/OR SELECTIVE METHYLATION BY DIAZOMETHANE OF ALCOHOLS, HALO ALCOHOLS, GLYCOLS, AMINO ALCOHOLS AND MERCAPTO ALCOHOLS WITH THE USE OF A PROTON-EXCHANGED X-TYPE ZEOLITE AS AN ACID-BASE BIFUNCTIONAL CATALYST". . p. 121 - 126. Retrieved 2007/10/02.