(5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenyl-3-(2-phenylethyl)heptanoyl amide

Base Information

Chemical Name:(5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenyl-3-(2-phenylethyl)heptanoyl amide
CAS No.:866227-30-7
Molecular Formula:C₂₅H₃₅N₃O₄
Molecular Weight:441.571
Hs Code.:

Synonyms:(5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenyl-3-(2-phenylethyl)heptanoyl amide

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Chemical Property of (5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenyl-3-(2-phenylethyl)heptanoyl amide

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Technology Process of (5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenyl-3-(2-phenylethyl)heptanoyl amide

There total 3 articles about (5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenyl-3-(2-phenylethyl)heptanoyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 866227-22-7
(2S,3S)-3-[N-(tert-butyloxycarbonyl)amino]-4-phenyl-1-[(2-phenylethyl)amino]butan-2-ol

: 96-32-2
bromoacetic acid methyl ester

: 866227-30-7
(5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenyl-3-(2-phenylethyl)heptanoyl amide

Guidance literature:: (2S,3S)-3-[N-(tert-butyloxycarbonyl)amino]-4-phenyl-1-[(2-phenylethyl)amino]butan-2-ol; bromoacetic acid methyl ester; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

With ammonia; In methanol; at 20 ℃;
DOI:10.1016/j.bmc.2005.06.048

Reference yield:

: 98760-08-8
(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane

: 866227-30-7
(5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenyl-3-(2-phenylethyl)heptanoyl amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 88 percent / propan-2-ol / 50 °C

2.1: K₂CO₃ / dimethylformamide / 20 °C

2.2: 70 percent / ammonia / methanol / 20 °C

With potassium carbonate; In N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmc.2005.06.048

Reference yield:

: 64-04-0
phenethylamine

: 866227-30-7
(5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenyl-3-(2-phenylethyl)heptanoyl amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 88 percent / propan-2-ol / 50 °C

2.1: K₂CO₃ / dimethylformamide / 20 °C

2.2: 70 percent / ammonia / methanol / 20 °C

With potassium carbonate; In N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmc.2005.06.048