(2S,3S)-3-[N-(tert-butyloxycarbonyl)amino]-4-phenyl-1-[(2-phenylethyl)amino]butan-2-ol

Base Information

• Chemical Name: (2S,3S)-3-[N-(tert-butyloxycarbonyl)amino]-4-phenyl-1-[(2-phenylethyl)amino]butan-2-ol
• CAS No.: 866227-22-7
• Molecular Formula: C₂₃H₃₂N₂O₃
• Molecular Weight: 384.519

Synonyms:(2S,3S)-3-[N-(tert-butyloxycarbonyl)amino]-4-phenyl-1-[(2-phenylethyl)amino]butan-2-ol

Chemical Property of (2S,3S)-3-[N-(tert-butyloxycarbonyl)amino]-4-phenyl-1-[(2-phenylethyl)amino]butan-2-ol

Chemical Property:

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Technology Process of (2S,3S)-3-[N-(tert-butyloxycarbonyl)amino]-4-phenyl-1-[(2-phenylethyl)amino]butan-2-ol

There total 1 articles about (2S,3S)-3-[N-(tert-butyloxycarbonyl)amino]-4-phenyl-1-[(2-phenylethyl)amino]butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane (98760-08-8) + phenethylamine (64-04-0) → (2S,3S)-3-[N-(tert-butyloxycarbonyl)amino]-4-phenyl-1-[(2-phenylethyl)amino]butan-2-ol (866227-22-7)

Guidance literature:

In isopropyl alcohol; at 50 ℃;

DOI:10.1016/j.bmc.2005.06.048

Reference yield: 70.0%

(2S,3S)-3-[N-(tert-butyloxycarbonyl)amino]-4-phenyl-1-[(2-phenylethyl)amino]butan-2-ol (866227-22-7) + bromoacetic acid methyl ester (96-32-2) → (5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenyl-3-(2-phenylethyl)heptanoyl amide (866227-30-7)

Guidance literature:

(2S,3S)-3-[N-(tert-butyloxycarbonyl)amino]-4-phenyl-1-[(2-phenylethyl)amino]butan-2-ol; bromoacetic acid methyl ester; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

With ammonia; In methanol; at 20 ℃;

DOI:10.1016/j.bmc.2005.06.048

Reference yield:

(2S,3S)-3-[N-(tert-butyloxycarbonyl)amino]-4-phenyl-1-[(2-phenylethyl)amino]butan-2-ol (866227-22-7) + bromoacetic acid methyl ester (96-32-2) → [(S)-1-((S)-6-Oxo-4-phenethyl-morpholin-2-yl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester + [((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyl)-phenethyl-amino]-acetic acid methyl ester

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmc.2005.06.048

upstream raw materials:

(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane

phenethylamine

Downstream raw materials:

(5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenyl-3-(2-phenylethyl)heptanoyl amide

(5S,6S)-3-aza-6-{[(tert-butyloxycarbonyl)-L-valinyl]amino}-5-hydroxy-7-phenyl-3-(2-phenylethyl)heptanoyl amide

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