(S,S,S)-1,3,5-tris[(2-benzyloxycarbonylamino)-2-methoxycarbonylethyl]benzene

Base Information

• Chemical Name: (S,S,S)-1,3,5-tris[(2-benzyloxycarbonylamino)-2-methoxycarbonylethyl]benzene
• CAS No.: 219583-65-0
• Molecular Formula: C₄₂H₄₅N₃O₁₂
• Molecular Weight: 783.832
• Mol file: 219583-65-0.mol

Synonyms:(S,S,S)-1,3,5-tris[(2-benzyloxycarbonylamino)-2-methoxycarbonylethyl]benzene

Chemical Property of (S,S,S)-1,3,5-tris[(2-benzyloxycarbonylamino)-2-methoxycarbonylethyl]benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S,S,S)-1,3,5-tris[(2-benzyloxycarbonylamino)-2-methoxycarbonylethyl]benzene

There total 3 articles about (S,S,S)-1,3,5-tris[(2-benzyloxycarbonylamino)-2-methoxycarbonylethyl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-benzyloxycarbonylamino-3-[3,5-bis-(2-benzyloxycarbonylamino-2-methoxycarbonyl-vinyl)-phenyl]-acrylic acid methyl ester (219583-57-0) → (S,S,S)-1,3,5-tris[(2-benzyloxycarbonylamino)-2-methoxycarbonylethyl]benzene (219583-65-0)

Guidance literature:

With benzene; hydrogen; In methanol; ethyl acetate; for 6h; under 2068.6 Torr; Ambient temperature;

DOI:10.1016/S0957-4166(98)00377-2

Reference yield:

benzene-1,3,5-trialdehyde (3163-76-6) → (S,S,S)-1,3,5-tris[(2-benzyloxycarbonylamino)-2-methoxycarbonylethyl]benzene (219583-65-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / N,N,N',N'-tetramethylguanidine / tetrahydrofuran / 4 h / Ambient temperature

2: 99 percent / H₂, >⁺*OTf^- / methanol; ethyl acetate / 6 h / 2068.6 Torr / Ambient temperature

With benzene; hydrogen; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; methanol; ethyl acetate;

DOI:10.1016/S0957-4166(98)00377-2

Reference yield:

N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester (100945-15-1,88568-95-0) → (S,S,S)-1,3,5-tris[(2-benzyloxycarbonylamino)-2-methoxycarbonylethyl]benzene (219583-65-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / N,N,N',N'-tetramethylguanidine / tetrahydrofuran / 4 h / Ambient temperature

2: 99 percent / H₂, >⁺*OTf^- / methanol; ethyl acetate / 6 h / 2068.6 Torr / Ambient temperature

With benzene; hydrogen; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; methanol; ethyl acetate;

DOI:10.1016/S0957-4166(98)00377-2

upstream raw materials:

2-benzyloxycarbonylamino-3-[3,5-bis-(2-benzyloxycarbonylamino-2-methoxycarbonyl-vinyl)-phenyl]-acrylic acid methyl ester

benzene-1,3,5-trialdehyde

N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester

Downstream raw materials:

(S,S,S)-2-amino-3-[3,5-bis(2-amino-2-(methoxycarbonyl)ethyl)phenyl]propanoic acid methyl ester

dimethyl (S,S,S)-2,2'-bis(tert-butyloxycarbonylamino)-3,3'-{5-[(2-tert-butyloxycarbonylamino)-2-(methoxycarbonyl)ethyl]-1,3-phenylene}bis(propanoate)

(S,S,S)-2,2'-bis(tert-butyloxycarbonylamino)-3,3'-{5-[(2-tert-butyloxycarbonylamino)-2-(methoxycarbonyl)ethyl]-1,3-phenylene}bis(propanoic acid)