2-benzyloxycarbonylamino-3-[3,5-bis-(2-benzyloxycarbonylamino-2-methoxycarbonyl-vinyl)-phenyl]-acrylic acid methyl ester

Base Information

• Chemical Name: 2-benzyloxycarbonylamino-3-[3,5-bis-(2-benzyloxycarbonylamino-2-methoxycarbonyl-vinyl)-phenyl]-acrylic acid methyl ester
• CAS No.: 219583-57-0
• Molecular Formula: C₄₂H₃₉N₃O₁₂
• Molecular Weight: 777.785
• Mol file: 219583-57-0.mol

Synonyms:2-benzyloxycarbonylamino-3-[3,5-bis-(2-benzyloxycarbonylamino-2-methoxycarbonyl-vinyl)-phenyl]-acrylic acid methyl ester

Chemical Property of 2-benzyloxycarbonylamino-3-[3,5-bis-(2-benzyloxycarbonylamino-2-methoxycarbonyl-vinyl)-phenyl]-acrylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzyloxycarbonylamino-3-[3,5-bis-(2-benzyloxycarbonylamino-2-methoxycarbonyl-vinyl)-phenyl]-acrylic acid methyl ester

There total 1 articles about 2-benzyloxycarbonylamino-3-[3,5-bis-(2-benzyloxycarbonylamino-2-methoxycarbonyl-vinyl)-phenyl]-acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

benzene-1,3,5-trialdehyde (3163-76-6) + N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester (100945-15-1,88568-95-0) → 2-benzyloxycarbonylamino-3-[3,5-bis-(2-benzyloxycarbonylamino-2-methoxycarbonyl-vinyl)-phenyl]-acrylic acid methyl ester (219583-57-0)

Guidance literature:

With N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1039/c8cc08618d

Reference yield: 99.0%

2-benzyloxycarbonylamino-3-[3,5-bis-(2-benzyloxycarbonylamino-2-methoxycarbonyl-vinyl)-phenyl]-acrylic acid methyl ester (219583-57-0) → (S,S,S)-1,3,5-tris[(2-benzyloxycarbonylamino)-2-methoxycarbonylethyl]benzene (219583-65-0)

Guidance literature:

With benzene; hydrogen; In methanol; ethyl acetate; for 6h; under 2068.6 Torr; Ambient temperature;

DOI:10.1016/S0957-4166(98)00377-2

Reference yield:

2-benzyloxycarbonylamino-3-[3,5-bis-(2-benzyloxycarbonylamino-2-methoxycarbonyl-vinyl)-phenyl]-acrylic acid methyl ester (219583-57-0) → 2-amino-3-[3,5-bis-(2-amino-2-methoxycarbonyl-ethyl)-phenyl]-propionic acid methyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / hydrogen / Wilkinson's catalyst / methanol; ethyl acetate / 120 h / 20 °C / 3102.89 Torr

2: hydrogen / Pd/C / methanol

With hydrogen; palladium on activated charcoal; Wilkinson's catalyst; In methanol; ethyl acetate;

DOI:10.1016/j.carres.2006.04.028

upstream raw materials:

benzene-1,3,5-trialdehyde

N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester

Downstream raw materials:

(S,S,S)-1,3,5-tris[(2-benzyloxycarbonylamino)-2-methoxycarbonylethyl]benzene

3-[3,5-bis(2-methoxycarbonyl-2-propynoylamino-ethyl)-phenyl]-2-propynoylamino-propionic acid methyl ester