3-{2-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methoxy-phenyl}-acrylic acid ethyl ester

Base Information

Chemical Name:3-{2-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methoxy-phenyl}-acrylic acid ethyl ester
CAS No.:853061-24-2
Molecular Formula:C₂₁H₃₄O₄Si
Molecular Weight:378.584
Hs Code.:

3-{2-[3-(<i>tert</i>-butyl-dimethyl-silanyloxy)-propyl]-4-methoxy-phenyl}-acrylic acid ethyl ester

Synonyms:3-{2-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methoxy-phenyl}-acrylic acid ethyl ester

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Chemical Property of 3-{2-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methoxy-phenyl}-acrylic acid ethyl ester

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Technology Process of 3-{2-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methoxy-phenyl}-acrylic acid ethyl ester

There total 6 articles about 3-{2-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methoxy-phenyl}-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 853061-14-0
2-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methoxy-benzaldehyde

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 853061-24-2
3-{2-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methoxy-phenyl}-acrylic acid ethyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.333333h;
DOI:10.1139/v05-259

Reference yield:

: 853061-12-8
2-(3-hydroxy-propyl)-4-methoxy-benzaldehyde

: 853061-24-2
3-{2-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methoxy-phenyl}-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / imidazole / tetrahydrofuran / 0.75 h / 20 °C

2: 97 percent / sodium hydride / tetrahydrofuran / 0.33 h / 20 °C

With 1H-imidazole; sodium hydride; In tetrahydrofuran; 2: Horner-Emmons reaction;
DOI:10.1139/v05-259

Reference yield:

: 52178-91-3
7-methoxy-1,2-dihydronaphthalene

: 853061-24-2
3-{2-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methoxy-phenyl}-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: O₃ / methanol / 1.5 h / -78 °C

1.2: sodium borohydride / methanol / 3 h / 20 °C

1.3: 86 percent / NaOH; hydrogen peroxide / tetrahydrofuran; H₂O / 18 h / 20 °C

2.1: 85 percent / manganese dioxide / pentane; CH₂Cl₂ / 20 °C

3.1: 100 percent / imidazole / tetrahydrofuran / 0.75 h / 20 °C

4.1: 97 percent / sodium hydride / tetrahydrofuran / 0.33 h / 20 °C

With 1H-imidazole; manganese(IV) oxide; sodium hydride; ozone; In tetrahydrofuran; methanol; dichloromethane; pentane; 4.1: Horner-Emmons reaction;
DOI:10.1139/v05-259