N-[benzyloxycarbonyl]-2-methylalanyl-2-methylalanyl-2-methylalanyl-L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide

Base Information

• Chemical Name: N-[benzyloxycarbonyl]-2-methylalanyl-2-methylalanyl-2-methylalanyl-L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide
• CAS No.: 1312775-30-6
• Molecular Formula: C₄₄H₆₄N₈O₉
• Molecular Weight: 849.04
• Mol file: 1312775-30-6.mol

Synonyms:N-[benzyloxycarbonyl]-2-methylalanyl-2-methylalanyl-2-methylalanyl-L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide

Chemical Property of N-[benzyloxycarbonyl]-2-methylalanyl-2-methylalanyl-2-methylalanyl-L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[benzyloxycarbonyl]-2-methylalanyl-2-methylalanyl-2-methylalanyl-L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide

There total 13 articles about N-[benzyloxycarbonyl]-2-methylalanyl-2-methylalanyl-2-methylalanyl-L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide (1312775-28-2) + 2-<2-<2-(Benzyloxycarboxamido)-2-methylpropionamido>-2-methylpropionamido>-2-methylpropionsaeure (4512-41-8) → N-[benzyloxycarbonyl]-2-methylalanyl-2-methylalanyl-2-methylalanyl-L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide (1312775-30-6)

Guidance literature:

2-<2-<2-(Benzyloxycarboxamido)-2-methylpropionamido>-2-methylpropionamido>-2-methylpropionsaeure; With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 ℃; for 0.05h;

L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide; With zinc(II) chloride; In N,N-dimethyl-formamide; at 20 ℃; for 40h; Inert atmosphere;

DOI:10.1002/hlca.201100116

Reference yield:

Z-Aib-OH (15030-72-5) → N-[benzyloxycarbonyl]-2-methylalanyl-2-methylalanyl-2-methylalanyl-L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide (1312775-30-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: diethyl ether / 0 - 20 °C

2.1: hydrogenchloride; water / tetrahydrofuran / 20 °C

3.1: tetrahydrofuran / 4.16 h / 0 - 20 °C

4.1: hydrogenchloride; water / tetrahydrofuran / 2 h / 20 °C

5.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 0.05 h / 0 °C

5.2: 40 h / 20 °C / Inert atmosphere

With hydrogenchloride; water; dicyclohexyl-carbodiimide; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1002/hlca.201100116

Reference yield:

2-<2-(Benzyloxycarboxamido)-2-methylpropionamido>-2-methylpropionsaeure (79775-03-4) → N-[benzyloxycarbonyl]-2-methylalanyl-2-methylalanyl-2-methylalanyl-L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide (1312775-30-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 4.16 h / 0 - 20 °C

2.1: hydrogenchloride; water / tetrahydrofuran / 2 h / 20 °C

3.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 0.05 h / 0 °C

3.2: 40 h / 20 °C / Inert atmosphere

With hydrogenchloride; water; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1002/hlca.201100116

upstream raw materials:

N-[benzyloxycarbonyl]-L-prolyl-2-methylalanine-N-methyl-N-phenylamide

N-[benzyloxycarbonyl]-L-prolyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide

N-[benzyloxycarbonyl]-L-prolyl-2-methylalanyl-2-methylalanine

N-[benzyloxycarbonyl]-L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide