L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide

Base Information

• Chemical Name: L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide
• CAS No.: 1312775-28-2
• Molecular Formula: C₂₄H₃₇N₅O₄
• Molecular Weight: 459.589
• Mol file: 1312775-28-2.mol

Synonyms:L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide

Chemical Property of L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide

There total 6 articles about L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N-[benzyloxycarbonyl]-L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide (1312775-26-0) → L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide (1312775-28-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 2h;

DOI:10.1002/hlca.201100116

Reference yield:

N-[benzyloxycarbonyl]-L-prolyl-2-methylalanine-N-methyl-N-phenylamide (1312775-22-6) → L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide (1312775-28-2)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogenchloride; water / tetrahydrofuran / 2.75 h / 20 °C

2: diethyl ether / 0 °C / Inert atmosphere

3: hydrogenchloride; water / tetrahydrofuran / 3.5 h / 20 °C

4: tetrahydrofuran; N,N-dimethyl-formamide / 45 h / 0 - 20 °C / Inert atmosphere

5: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; water; hydrogen; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1002/hlca.201100116

Reference yield:

N-[benzyloxycarbonyl]-L-prolyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide (1312775-23-7) → L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide (1312775-28-2)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride; water / tetrahydrofuran / 3.5 h / 20 °C

2: tetrahydrofuran; N,N-dimethyl-formamide / 45 h / 0 - 20 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; water; hydrogen; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1002/hlca.201100116

upstream raw materials:

N-[benzyloxycarbonyl]-L-prolyl-2-methylalanine-N-methyl-N-phenylamide

N-[benzyloxycarbonyl]-L-prolyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide

N-[benzyloxycarbonyl]-L-prolyl-2-methylalanyl-2-methylalanine

N-[benzyloxycarbonyl]-L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide

Downstream raw materials:

N-[benzyloxycarbonyl]-2-methylalanyl-2-methylalanyl-2-methylalanyl-L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide