2-(1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-imidazol-4-yl)-2-methylpropanoic acid

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Chemical Name:2-(1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-imidazol-4-yl)-2-methylpropanoic acid
CAS No.:937055-97-5
Molecular Formula:C₂₉H₃₀ClN₃O₅
Molecular Weight:536.027
Hs Code.:

Synonyms:2-(1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-imidazol-4-yl)-2-methylpropanoic acid

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Chemical Property of 2-(1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-imidazol-4-yl)-2-methylpropanoic acid

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Technology Process of 2-(1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-imidazol-4-yl)-2-methylpropanoic acid

There total 10 articles about 2-(1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-imidazol-4-yl)-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 937055-96-4
Ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-imidazol-4-yl)-2-methylpropanoate

: 937055-97-5
2-(1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-imidazol-4-yl)-2-methylpropanoic acid

Guidance literature:: Ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-imidazol-4-yl)-2-methylpropanoate; With methanol; sodium hydroxide; water; In tetrahydrofuran; Heating / reflux;

With water; citric acid;

Reference yield:

: 937057-48-2
[5-chloro-2-(1H-pyrrol-1-yl)phenyl](2,3-dimethoxyphenyl)methanone

: 937055-97-5
2-(1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-imidazol-4-yl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: trichlorophosphate / 0.17 h / 0 - 20 °C

1.2: 2 h / 50 °C / Heating / reflux

1.3: 0.5 h / Heating / reflux

2.1: toluene / 100 °C

3.1: sodium tetrahydroborate / methanol / 1 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 20 °C

5.1: Resolution of racemate

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

6.2: 3 h / 0 °C

7.1: triethylamine / dichloromethane / 3 h / 0 °C

8.1: potassium carbonate / tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 4 h / 70 °C

9.1: methanol; sodium hydroxide; water / tetrahydrofuran / Heating / reflux

With methanol; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; water; potassium carbonate; triethylamine; trifluoroacetic acid; trichlorophosphate; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 937054-13-2
methyl 2-[8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate

: 937055-97-5
2-(1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-imidazol-4-yl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: Resolution of racemate

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

2.2: 3 h / 0 °C

3.1: triethylamine / dichloromethane / 3 h / 0 °C

4.1: potassium carbonate / tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 4 h / 70 °C

5.1: methanol; sodium hydroxide; water / tetrahydrofuran / Heating / reflux

With methanol; sodium hydroxide; lithium aluminium tetrahydride; water; potassium carbonate; triethylamine; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;