6-{N-[4-amino-3-(difluoromethyl)phenyl]methanesulfonamido}-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

Base Information

Chemical Name:6-{N-[4-amino-3-(difluoromethyl)phenyl]methanesulfonamido}-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide
CAS No.:1423007-62-8
Molecular Formula:C₂₇H₂₂BrF₃N₂O₄S
Molecular Weight:607.448
Hs Code.:

Synonyms:6-{N-[4-amino-3-(difluoromethyl)phenyl]methanesulfonamido}-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

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Chemical Property of 6-{N-[4-amino-3-(difluoromethyl)phenyl]methanesulfonamido}-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

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Technology Process of 6-{N-[4-amino-3-(difluoromethyl)phenyl]methanesulfonamido}-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

There total 16 articles about 6-{N-[4-amino-3-(difluoromethyl)phenyl]methanesulfonamido}-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1423007-61-7
6-{N-[4-amino-3-(difluoromethyl)phenyl]methanesulfonamido}-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

: 1423007-62-8
6-{N-[4-amino-3-(difluoromethyl)phenyl]methanesulfonamido}-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

Guidance literature:: 6-{N-[4-amino-3-(difluoromethyl)phenyl]methanesulfonamido}-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide; With hydrogen bromide; sodium nitrite; In water; acetonitrile; at 0 ℃; for 0.5h;

With copper(I) bromide; In water; acetonitrile; at 75 ℃; for 2h;

Reference yield:

: 1214333-17-1
2-(difluoromethyl)-4-fluoro-1-nitrobenzene

: 1423007-62-8
6-{N-[4-amino-3-(difluoromethyl)phenyl]methanesulfonamido}-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N,N,N,N,N-hexamethylphosphoric triamide / 15 h / 60 °C

2.1: palladium 10% on activated carbon; hydrogenchloride / methanol / 3 h / 1034.32 Torr

3.1: hydrogen bromide; sodium nitrite / acetonitrile; water / 0.5 h / 0 °C

3.2: 2 h / 75 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen bromide; potassium carbonate; sodium nitrite; In methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; water; acetonitrile; 3.1: |Sandmeyer Reaction;

Reference yield:

: 1423007-60-6
5-cyclopropyl-6-{N-[3-(difluoromethyl)-4-nitrophenyl]methanesulfonamido}-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

: 1423007-62-8
6-{N-[4-amino-3-(difluoromethyl)phenyl]methanesulfonamido}-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogenchloride / methanol / 3 h / 1034.32 Torr

2.1: hydrogen bromide; sodium nitrite / acetonitrile; water / 0.5 h / 0 °C

2.2: 2 h / 75 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen bromide; sodium nitrite; In methanol; water; acetonitrile; 2.1: |Sandmeyer Reaction;