(4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-(difluoromethyl)phenyl)boronic acid

Base Information

Chemical Name:(4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-(difluoromethyl)phenyl)boronic acid
CAS No.:1423007-59-3
Molecular Formula:C₂₇H₂₄BF₃N₂O₆S
Molecular Weight:572.37
Hs Code.:

Synonyms:(4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-(difluoromethyl)phenyl)boronic acid

Suppliers and Price of (4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-(difluoromethyl)phenyl)boronic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-(difluoromethyl)phenyl)boronic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-(difluoromethyl)phenyl)boronic acid

There total 19 articles about (4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-(difluoromethyl)phenyl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1423007-62-8
6-{N-[4-amino-3-(difluoromethyl)phenyl]methanesulfonamido}-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

: 73183-34-3
bis(pinacol)diborane

: 1423007-59-3
(4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-(difluoromethyl)phenyl)boronic acid

Guidance literature:: 6-{N-[4-amino-3-(difluoromethyl)phenyl]methanesulfonamido}-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide; bis(pinacol)diborane; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 80 ℃; for 3.75h; Inert atmosphere;

With hydrogenchloride; sodium periodate; In tetrahydrofuran; water; for 1h;

Reference yield:

: C₃₃H₃₄BF₃N₂O₆S

: 1423007-59-3
(4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-(difluoromethyl)phenyl)boronic acid

Guidance literature:: With hydrogenchloride; sodium periodate; water; In tetrahydrofuran; for 1h; Inert atmosphere;

Reference yield:

: 1214333-17-1
2-(difluoromethyl)-4-fluoro-1-nitrobenzene

: 1423007-59-3
(4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-(difluoromethyl)phenyl)boronic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N,N,N,N,N-hexamethylphosphoric triamide / 15 h / 60 °C

2.1: palladium 10% on activated carbon; hydrogenchloride / methanol / 3 h / 1034.32 Torr

3.1: hydrogen bromide; sodium nitrite / acetonitrile; water / 0.5 h / 0 °C

3.2: 2 h / 75 °C

4.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 3.75 h / 80 °C / Inert atmosphere

4.2: 1 h

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen bromide; potassium acetate; potassium carbonate; sodium nitrite; In 1,4-dioxane; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; water; acetonitrile; 3.1: |Sandmeyer Reaction;