Technology Process of 2-nitro-<α-D>-styrene
There total 6 articles about 2-nitro-<α-D>-styrene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Methyltriphenylphosphonium bromide;
With
n-butyllithium;
In
tetrahydrofuran; cyclohexane;
at 0 - 20 ℃;
for 1h;
Inert atmosphere;
2-nitrobenzaldehyde-α-d1;
In
tetrahydrofuran; cyclohexane;
at 65 ℃;
for 5h;
DOI:10.1002/anie.201402661
- Guidance literature:
-
Multi-step reaction with 2 steps
1: BuLi, Ph3P / tetrahydrofuran
2: HNO3 / acetic anhydride
With
n-butyllithium; nitric acid; triphenylphosphine;
In
tetrahydrofuran; acetic anhydride;
DOI:10.1002/oms.1210181214
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium aluminium deuteride / diethyl ether / 0 - 20 °C / Inert atmosphere; Schlenk technique
2.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
3.1: n-butyllithium / tetrahydrofuran; cyclohexane / 1 h / 0 - 20 °C / Inert atmosphere
3.2: 5 h / 65 °C
With
n-butyllithium; lithium aluminium deuteride; Dess-Martin periodane;
In
tetrahydrofuran; diethyl ether; dichloromethane; cyclohexane;
DOI:10.1002/anie.201402661
