2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 2,2-dimethyl-propionyloxymethyl ester

Base Information

Chemical Name:2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 2,2-dimethyl-propionyloxymethyl ester
CAS No.:210988-82-2
Molecular Formula:C₅₃H₅₅N₇O₅
Molecular Weight:870.064
Hs Code.:

2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 2,2-dimethyl-propionyloxymethyl ester

Synonyms:2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 2,2-dimethyl-propionyloxymethyl ester

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Chemical Property of 2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 2,2-dimethyl-propionyloxymethyl ester

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Technology Process of 2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 2,2-dimethyl-propionyloxymethyl ester

There total 10 articles about 2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 2,2-dimethyl-propionyloxymethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3350-78-5
3,3-Dimethylacryloyl chloride

: 210988-82-2
2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 2,2-dimethyl-propionyloxymethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 72 percent / pyridine / 1.5 h

2: 71 percent / NaH / dimethylformamide / Ambient temperature

3: 91 percent / AcOH / ethanol / 3 h / Heating

4: 73 percent / 1N aq. NaOH / ethanol / Ambient temperature

5: 86 percent / Et₃N / dimethylformamide

6: 1.) 0.1N ethanolic KOH, 2.) 10percent aq. NaI / 2.) acetone, reflux, 8 h

With pyridine; potassium hydroxide; sodium hydroxide; sodium hydride; acetic acid; triethylamine; sodium iodide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.973

Reference yield:

: ethyl N-cyanovalerimidate

: 210988-82-2
2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 2,2-dimethyl-propionyloxymethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: Et₃N / ethanol / Ambient temperature

2: 1.) NaH / 1.) DMF, 5 min, 2.) DMF, RT, 2 h

3: NaH / dimethylformamide / 3 h / Ambient temperature

4: 72 percent / pyridine / 1.5 h

5: 71 percent / NaH / dimethylformamide / Ambient temperature

6: 91 percent / AcOH / ethanol / 3 h / Heating

7: 73 percent / 1N aq. NaOH / ethanol / Ambient temperature

8: 86 percent / Et₃N / dimethylformamide

9: 1.) 0.1N ethanolic KOH, 2.) 10percent aq. NaI / 2.) acetone, reflux, 8 h

With pyridine; potassium hydroxide; sodium hydroxide; sodium hydride; acetic acid; triethylamine; sodium iodide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.973

Reference yield:

: 133614-30-9
N-(N'-cyanovalerimidolyl)glycine ethyl ester

: 210988-82-2
2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 2,2-dimethyl-propionyloxymethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) NaH / 1.) DMF, 5 min, 2.) DMF, RT, 2 h

2: NaH / dimethylformamide / 3 h / Ambient temperature

3: 72 percent / pyridine / 1.5 h

4: 71 percent / NaH / dimethylformamide / Ambient temperature

5: 91 percent / AcOH / ethanol / 3 h / Heating

6: 73 percent / 1N aq. NaOH / ethanol / Ambient temperature

7: 86 percent / Et₃N / dimethylformamide

8: 1.) 0.1N ethanolic KOH, 2.) 10percent aq. NaI / 2.) acetone, reflux, 8 h

With pyridine; potassium hydroxide; sodium hydroxide; sodium hydride; acetic acid; triethylamine; sodium iodide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.973