2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid

Base Information

Chemical Name:2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid
CAS No.:210988-74-2
Molecular Formula:C₄₇H₄₅N₇O₃
Molecular Weight:755.919
Hs Code.:

Synonyms:2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid

There total 9 articles about 2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 76-83-5
trityl chloride

: 149586-21-0
2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid

: 210988-74-2
2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.973

Reference yield:

: 3350-78-5
3,3-Dimethylacryloyl chloride

: 210988-74-2
2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / pyridine / 1.5 h

2: 71 percent / NaH / dimethylformamide / Ambient temperature

3: 91 percent / AcOH / ethanol / 3 h / Heating

4: 73 percent / 1N aq. NaOH / ethanol / Ambient temperature

5: 86 percent / Et₃N / dimethylformamide

With pyridine; sodium hydroxide; sodium hydride; acetic acid; triethylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.973

Reference yield:

: ethyl N-cyanovalerimidate

: 210988-74-2
2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1: Et₃N / ethanol / Ambient temperature

2: 1.) NaH / 1.) DMF, 5 min, 2.) DMF, RT, 2 h

3: NaH / dimethylformamide / 3 h / Ambient temperature

4: 72 percent / pyridine / 1.5 h

5: 71 percent / NaH / dimethylformamide / Ambient temperature

6: 91 percent / AcOH / ethanol / 3 h / Heating

7: 73 percent / 1N aq. NaOH / ethanol / Ambient temperature

8: 86 percent / Et₃N / dimethylformamide

With pyridine; sodium hydroxide; sodium hydride; acetic acid; triethylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.973