(2S)-2-(2-fluoro-biphenyl-4-yl)-propan-1-ol

Base Information

• Chemical Name: (2S)-2-(2-fluoro-biphenyl-4-yl)-propan-1-ol
• CAS No.: 189130-24-3
• Molecular Formula: C₁₅H₁₅FO
• Molecular Weight: 230.282
• Mol file: 189130-24-3.mol

Synonyms:(2S)-2-(2-fluoro-biphenyl-4-yl)-propan-1-ol

Chemical Property of (2S)-2-(2-fluoro-biphenyl-4-yl)-propan-1-ol

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (2S)-2-(2-fluoro-biphenyl-4-yl)-propan-1-ol

There total 1 articles about (2S)-2-(2-fluoro-biphenyl-4-yl)-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-fluoro-biphenyl-4-yl)-propionaldehyde (56430-76-3) → 3'-fluoro-4'-phenylacetophenone (42771-79-9) + (2S)-2-(2-fluoro-biphenyl-4-yl)-propan-1-ol (189130-24-3)

Guidance literature:

With ethanol; horse liver alcohol dehydrogenase; β-nicotinamide adenine dinucleotide, reduced dipotassium salt; In acetonitrile; for 96.25h; pH=8; enantioselective reaction; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1039/c005098a

Reference yield: 99.0%

(2S)-2-(2-fluoro-biphenyl-4-yl)-propan-1-ol (189130-24-3) → (S)-(+)-flurbiprofen (5104-49-4,51543-38-5,51543-39-6,51543-40-9)

Guidance literature:

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; laccase from Trametes versicolor; oxygen; In water; dimethyl sulfoxide; at 20 ℃; for 168h; Enzymatic reaction;

DOI:10.1002/cssc.201402136

Reference yield: 47.0%

(2S)-2-(2-fluoro-biphenyl-4-yl)-propan-1-ol (189130-24-3) → 3'-fluoro-4'-phenylacetophenone (42771-79-9) + (S)-(+)-flurbiprofen (5104-49-4,51543-38-5,51543-39-6,51543-40-9)

Guidance literature:

With potassium permanganate; sulfuric acid; In acetone; at 0 - 20 ℃; for 4.5h;

DOI:10.1055/s-0030-1258580

upstream raw materials:

2-(2-fluoro-biphenyl-4-yl)-propionaldehyde

Downstream raw materials:

(S)-(+)-flurbiprofen

3'-fluoro-4'-phenylacetophenone