3-(4-(2-(2-(1H-imidazol-4-yl)phenoxy)ethyl)phenyl)-1-hydroxy-1-(tetrahydro-2H-pyran-4-yl)urea

Base Information

Chemical Name:3-(4-(2-(2-(1H-imidazol-4-yl)phenoxy)ethyl)phenyl)-1-hydroxy-1-(tetrahydro-2H-pyran-4-yl)urea
CAS No.:1300730-18-0
Molecular Formula:C₂₃H₂₆N₄O₄
Molecular Weight:422.484
Hs Code.:

Synonyms:3-(4-(2-(2-(1H-imidazol-4-yl)phenoxy)ethyl)phenyl)-1-hydroxy-1-(tetrahydro-2H-pyran-4-yl)urea

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Chemical Property of 3-(4-(2-(2-(1H-imidazol-4-yl)phenoxy)ethyl)phenyl)-1-hydroxy-1-(tetrahydro-2H-pyran-4-yl)urea

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Technology Process of 3-(4-(2-(2-(1H-imidazol-4-yl)phenoxy)ethyl)phenyl)-1-hydroxy-1-(tetrahydro-2H-pyran-4-yl)urea

There total 5 articles about 3-(4-(2-(2-(1H-imidazol-4-yl)phenoxy)ethyl)phenyl)-1-hydroxy-1-(tetrahydro-2H-pyran-4-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₂H₄₀N₄O₄

: 1300730-18-0
3-(4-(2-(2-(1H-imidazol-4-yl)phenoxy)ethyl)phenyl)-1-hydroxy-1-(tetrahydro-2H-pyran-4-yl)urea

Guidance literature:: C₄₂H₄₀N₄O₄; With acetic acid; In methanol; at 80 ℃; for 2h;

With sodium hydroxide; In methanol; water;

Reference yield:

: 104-10-9
2-(4'-aminophenyl)ethyl alcohol

: 1300730-18-0
3-(4-(2-(2-(1H-imidazol-4-yl)phenoxy)ethyl)phenyl)-1-hydroxy-1-(tetrahydro-2H-pyran-4-yl)urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid / 1 h / 100 °C

2.1: pyridine / dichloromethane / 16 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

3.2: Inert atmosphere

4.1: hydrazine hydrate / ethanol / 2 h / 80 °C

5.1: triethylamine / dichloromethane / 2 h / Reflux

5.2: 2 h / 20 °C / Cooling with ice

6.1: acetic acid / methanol / 2 h / 80 °C

With pyridine; sodium hydride; hydrazine hydrate; acetic acid; triethylamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: C₄₄H₃₃N₃O₃

: 1300730-18-0
3-(4-(2-(2-(1H-imidazol-4-yl)phenoxy)ethyl)phenyl)-1-hydroxy-1-(tetrahydro-2H-pyran-4-yl)urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate / ethanol / 2 h / 80 °C

2.1: triethylamine / dichloromethane / 2 h / Reflux

2.2: 2 h / 20 °C / Cooling with ice

3.1: acetic acid / methanol / 2 h / 80 °C

With hydrazine hydrate; acetic acid; triethylamine; In methanol; ethanol; dichloromethane;