2-(4-Aminophenyl)ethanol

Base Information

• Chemical Name: 2-(4-Aminophenyl)ethanol
• CAS No.: 104-10-9
• Molecular Formula: C8H11NO
• Molecular Weight: 137.181
• Hs Code.: 29221990
• European Community (EC) Number: 203-174-8
• NSC Number: 409780
• UNII: KVH9V2607F
• DSSTox Substance ID: DTXSID7073066
• Nikkaji Number: J28.544G
• Wikidata: Q27282460
• Mol file: 104-10-9.mol

Synonyms:2-(4-Aminophenyl)ethanol;104-10-9;4-Aminophenethyl alcohol;p-Aminophenethyl alcohol;Benzeneethanol, 4-amino-;2-(p-Aminophenyl)ethanol;p-Aminophenylethanol;4-(2-Hydroxyethyl)aniline;p-(2-Hydroxyethyl)aniline;2-(4-aminophenyl)ethan-1-ol;Phenethyl alcohol, p-amino-;MFCD00007922;Benzeneethanol, ar-amino-;4-Aminobenzeneethanol;2-(4-Aminophenyl)ethyl Alcohol;Benzeneethanol, ar-amino;2-(4-AMINO-PHENYL)-ETHANOL;NSC 409780;2-(4-aminophenyl)-ethanol;UNII-KVH9V2607F;KVH9V2607F;EINECS 203-174-8;NSC-409780;AI3-18010;115341-06-5;4-AMINOPHENYLETHYL ALCOHOL;p-Aminophenylethyl alcohol;4-Aminophenylethanol;4-aminophenethylalcohol;C(CO)c1ccc(N)cc1;4-aminophenylethylalcohol;2-(4aminophenyl)ethanol;4-amino-phenethyl alcohol;2-(4-aminopheny)-ethanol;SCHEMBL6051;2-(4-amino phenyl)ethanol;2-(4-aminophenyl) ethanol;4-(2-hydroxyethyl) aniline;Oprea1_680230;(4-aminophenyl)ethyl alcohol;2-[(4-amino)phenyl]ethanol;4-Aminophenethyl alcohol, 98%;DTXSID7073066;STR05200;BBL036337;NSC409780;STK365308;AKOS000268898;2-(4-AMINOPHENYL)-1-ETHANOL;AM84233;CS-W005059;SY030989;A0394;FT-0608580;EN300-53053;W-108826;Q27282460;F0465-0001;Z276600190

Chemical Property of 2-(4-Aminophenyl)ethanol

Chemical Property:

• Appearance/Colour: light brown to brown crystals
• Vapor Pressure: 0.00115mmHg at 25°C
• Melting Point: 104-108 °C
• Refractive Index: 1.596
• Boiling Point: 287.5 °C at 760 mmHg
• PKA: 15.05±0.10(Predicted)
• Flash Point: 127.7 °C
• PSA: 46.25000
• Density: 1.124 g/cm³
• LogP: 1.38480
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: Soluble in methanol.
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 137.084063974
• Heavy Atom Count: 10
• Complexity: 87.3

Purity/Quality:

99% ^*data from raw suppliers

4-Aminophenethyl alcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1CCO)N
• Uses: 2-(4-Aminophenyl)ethanol is used as nonsymmetric monomer in the preparation of ordered [head-to-head (H-H) or tail-to-tail (T-T)] poly(amide-ester), in the synthesis of 4-aminostyrene and in functionalization of graphene nanoplatelets. 4-Aminophenethyl alcohol has been used:as nonsymmetric monomer in the preparation of ordered [head-to-head (H-H) or tail-to-tail (T-T)] poly(amide-ester)in the synthesis of 4-aminostyrenein functionalization of graphene nanoplatelets

Technology Process of 2-(4-Aminophenyl)ethanol

There total 20 articles about 2-(4-Aminophenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.7%

2-(4-nitrophenyl)ethanol (100-27-6) → 2-(4'-aminophenyl)ethyl alcohol (104-10-9)

Guidance literature:

With hydrogenchloride; hydrazine hydrate; sodium hydroxide; In methanol; water; at 68 ℃; pH=7; Reagent/catalyst; pH-value;

Reference yield: 99.0%

methyl (4-(2-hydroxyethyl)phenyl)carbamate → 2-(4'-aminophenyl)ethyl alcohol (104-10-9)

Guidance literature:

With 3-azapentane-1,5-diamine; at 130 ℃; for 12h; Sealed tube;

DOI:10.1021/acs.orglett.6b03016

Reference yield: 95.7%

β-(2,4-dinitrophenyl)ethyl nitrate (1081-79-4) → 2-(4'-aminophenyl)ethyl alcohol (104-10-9)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In isopropyl alcohol; at 40 ℃; for 3h; Temperature; Time;

DOI:10.1007/s11172-015-1140-y

upstream raw materials:

2-(4-nitrophenyl)ethanol

β-(2,4-dinitrophenyl)ethyl nitrate

acetic acid phenethyl ester

ETHYL 4-NITROPHENYLACETATE

Downstream raw materials:

1-amino-2-chloro-9,10-anthraquinone

1-Amino-2-chloro-4-[4-(2-hydroxy-ethyl)-phenylamino]-anthraquinone

2-<4-(1-piperazinyl)phenyl>ethyl alcohol

4-(2-hydroxyethyl)benzonitrile

Refernces

• 1、 Channe Gowda,Prakasha Gowda,Ramesha Baba,Gowda, Shankare. "Nickel-catalyzed formic acid reductions. A selective method for the reduction of nitro compounds". . p. 2889 - 2895. Retrieved 2000.
• 2、 Bao, Lingxiang,Fei, Teng,Li, Jiazhe,Pang, Siping,Sun, Chenghui,Yan, Zhiyuan,Yu, Zongbao. "Palladium supported on metal–organic framework as a catalyst for the hydrogenation of nitroarenes under mild conditions". . . Retrieved 2020.
• 3、 Arya, Kapil,Dandia, Anshu. "Selective reduction of nitro compounds using CeY zeolite under microwaves". . p. 55 - 58. Retrieved 2010.
• 4、 Gowda, Shankare,Gowda, B. K. Kempe,Gowda, D. Channe. "Hydrazinium monoformate: A new hydrogen donor. Selective reduction of nitrocompounds catalyzed by commercial zinc dust". . p. 281 - 289. Retrieved 2003.
• 5、 Kochergin, P. M.,Mikhailova, I. S.,Aleksandrova, E. V.. "The Synthesis of (Aminophenyl)alkanols by Hydrogenation of (Nitrophenyl)alkanol Nitroesters". . p. 598 - 599. Retrieved 1998.
• 6、 -. "Method for preparing amine through catalytic reduction of nitro compound by cyclic (alkyl) (amino) carbene chromium complex". Paragraph 0015. . Retrieved 2021/04/17.
• 7、 -. "ADENOSINE RECEPTOR BINDING COMPOUNDS". Paragraph 00240. . Retrieved 2020/02/06.