1,7-dimethyl-3-(2-methyl-5-(5-phenyl-1,2,4-oxadiazol-3-ylamino)phenyl)-1,6-naphthyridin-2(1H)-one

Base Information

• Chemical Name: 1,7-dimethyl-3-(2-methyl-5-(5-phenyl-1,2,4-oxadiazol-3-ylamino)phenyl)-1,6-naphthyridin-2(1H)-one
• CAS No.: 1185279-55-3
• Molecular Formula: C₂₅H₂₁N₅O₂
• Molecular Weight: 423.474
• Mol file: 1185279-55-3.mol

Synonyms:1,7-dimethyl-3-(2-methyl-5-(5-phenyl-1,2,4-oxadiazol-3-ylamino)phenyl)-1,6-naphthyridin-2(1H)-one

Chemical Property of 1,7-dimethyl-3-(2-methyl-5-(5-phenyl-1,2,4-oxadiazol-3-ylamino)phenyl)-1,6-naphthyridin-2(1H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,7-dimethyl-3-(2-methyl-5-(5-phenyl-1,2,4-oxadiazol-3-ylamino)phenyl)-1,6-naphthyridin-2(1H)-one

There total 19 articles about 1,7-dimethyl-3-(2-methyl-5-(5-phenyl-1,2,4-oxadiazol-3-ylamino)phenyl)-1,6-naphthyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-methyl N'-benzoyl-N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)carbamimidothioate (1185855-74-6) → 1,7-dimethyl-3-(2-methyl-5-(5-phenyl-1,2,4-oxadiazol-3-ylamino)phenyl)-1,6-naphthyridin-2(1H)-one (1185279-55-3)

Guidance literature:

With hydroxylamine hydrochloride; In ethanol; at 80 ℃; for 2h;

Reference yield:

(E)-1-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)-2-hydroxyguanidine (1185855-70-2) + benzoic acid (65-85-0,8013-63-6) → 1,7-dimethyl-3-(2-methyl-5-(5-phenyl-1,2,4-oxadiazol-3-ylamino)phenyl)-1,6-naphthyridin-2(1H)-one (1185279-55-3)

Guidance literature:

With sodium sulfate; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 - 100 ℃;

Reference yield:

(6-chloro-4-(methylamino)pyridin-3-yl)methanol (449811-30-7) → 1,7-dimethyl-3-(2-methyl-5-(5-phenyl-1,2,4-oxadiazol-3-ylamino)phenyl)-1,6-naphthyridin-2(1H)-one (1185279-55-3)

Guidance literature:

Multi-step reaction with 6 steps

1: manganese(IV) oxide / dichloromethane / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine / 1,4-dioxane; toluene / 0.17 h / 150 °C / Microwave irradiation

4: dichloromethane / 0.17 h / 20 °C

5: sodium hydroxide / dichloromethane / 1 h / 20 °C

6: hydroxylamine hydrochloride / ethanol / 2 h / 80 °C

With manganese(IV) oxide; hydroxylamine hydrochloride; potassium carbonate; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

upstream raw materials:

(E)-1-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)-2-hydroxyguanidine

benzoic acid

(Z)-methyl N'-benzoyl-N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)carbamimidothioate

2-(2-methyl-5-nitrophenyl)acetonitrile