Technology Process of (E)-1-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)-2-hydroxyguanidine
There total 16 articles about (E)-1-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)-2-hydroxyguanidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydroxylamine;
In
ethanol; water;
at 20 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: water; potassium hydroxide / methanol / 14 h / Reflux
2.1: hydrogenchloride / 1,4-dioxane / 14 h / Reflux
2.2: pH > 12
3.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C
5.1: tris-(dibenzylideneacetone)dipalladium(0); triphenylphosphine / 1,4-dioxane; toluene / 0.17 h / 150 °C / Microwave irradiation
6.1: potassium acetate / methanol / 0 - 20 °C
7.1: hydroxylamine / ethanol; water / 12 h / 20 °C
With
hydrogenchloride; water; hydrogen; hydroxylamine; potassium acetate; potassium carbonate; potassium hydroxide;
tris-(dibenzylideneacetone)dipalladium(0); palladium 10% on activated carbon; triphenylphosphine;
In
1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C
2: tris-(dibenzylideneacetone)dipalladium(0); triphenylphosphine / 1,4-dioxane; toluene / 0.17 h / 150 °C / Microwave irradiation
3: potassium acetate / methanol / 0 - 20 °C
4: hydroxylamine / ethanol; water / 12 h / 20 °C
With
hydroxylamine; potassium acetate; potassium carbonate;
tris-(dibenzylideneacetone)dipalladium(0); triphenylphosphine;
In
1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; toluene;
