(1R)-2-amino-1-(4-methoxyphenyl)ethan-1-ol

Base Information

• Chemical Name: (1R)-2-amino-1-(4-methoxyphenyl)ethan-1-ol
• CAS No.: 46084-23-5
• Molecular Formula: C₉H₁₃NO₂
• Molecular Weight: 167.208
• DSSTox Substance ID: DTXSID201254503
• Nikkaji Number: J1.371.223I
• Mol file: 46084-23-5.mol

Synonyms:(1R)-2-amino-1-(4-methoxyphenyl)ethan-1-ol;46084-23-5;(r)-methoxyphenylglycinol;SCHEMBL7152554;DTXSID201254503;46084-19-9;(R)-1-(p-Anisyl)-2-aminoethanol;AKOS006295830;EN300-250861;A826985;(alphaR)-alpha-(Aminomethyl)-4-methoxybenzenemethanol

Chemical Property of (1R)-2-amino-1-(4-methoxyphenyl)ethan-1-ol

Chemical Property:

• XLogP3: 0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 167.094628657
• Heavy Atom Count: 12
• Complexity: 122

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(CN)O
• Isomeric SMILES: COC1=CC=C(C=C1)[C@H](CN)O

Technology Process of (1R)-2-amino-1-(4-methoxyphenyl)ethan-1-ol

There total 22 articles about (1R)-2-amino-1-(4-methoxyphenyl)ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(R)-β-azido-α-(4-methoxyphenyl)ethanol (341513-45-9) → (R)-(-)-2-Amino-1-(4-methoxyphenyl)-1-ethanol (46084-23-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 3h; under 760 Torr;

DOI:10.1016/j.tetasy.2004.11.013

Reference yield: 92.0%

(R)-1-(4-methoxyphenyl)-2-nitroethanol (675579-61-0) → (R)-(-)-2-Amino-1-(4-methoxyphenyl)-1-ethanol (46084-23-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; under 760.051 Torr;

DOI:10.1002/cplu.201402078

Reference yield: 85.0%

(R)-(+)-α-Hydroxy-4-methoxybenzeneacetonitrile (97070-73-0) → (R)-(-)-2-Amino-1-(4-methoxyphenyl)-1-ethanol (46084-23-5)

Guidance literature:

With lithium aluminium tetrahydride; Ambient temperature;

DOI:10.1016/S0957-4166(00)82338-1

upstream raw materials:

(R)-(+)-α-Hydroxy-4-methoxybenzeneacetonitrile

(R)-(+)-α-<(tert-butyldimethylsilyl)oxy>-4-methoxybenzeneacetonitrile

N-[(R)-2-Hydroxy-2-(4-methoxy-phenyl)-ethyl]-acetamide

(R)-β-azido-α-(4-methoxyphenyl)ethanol

Downstream raw materials:

(R)-(-)-N-(2-hydroxy-2-(4-methoxyphenyl)ethyl)benzamide

C₂₇H₂₉NO₆

C₂₇H₂₉NO₆