Benzenemethanol, 4-methoxy-alpha-(nitromethyl)-, (alphaR)- (9CI)

Base Information

• Chemical Name: Benzenemethanol, 4-methoxy-alpha-(nitromethyl)-, (alphaR)- (9CI)
• CAS No.: 675579-61-0
• Molecular Formula: C9H11NO4
• Molecular Weight: 197.191
• Mol file: 675579-61-0.mol

Synonyms:Benzenemethanol, 4-methoxy-alpha-(nitromethyl)-, (alphaR)- (9CI)

Chemical Property of Benzenemethanol, 4-methoxy-alpha-(nitromethyl)-, (alphaR)- (9CI)

Chemical Property:

• PSA: 75.28000
• LogP: 1.52850

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanol, 4-methoxy-alpha-(nitromethyl)-, (alphaR)- (9CI)

There total 13 articles about Benzenemethanol, 4-methoxy-alpha-(nitromethyl)-, (alphaR)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

nitromethane (75-52-5) + 4-methoxy-benzaldehyde (123-11-5) → (R)-1-(4-methoxyphenyl)-2-nitroethanol (675579-61-0)

Guidance literature:

4-methoxy-benzaldehyde; With heptakis(6-amino-6-deoxy)-β-cyclodextrin; In water; acetone; acetonitrile;

nitromethane; In water; acetone; acetonitrile; at -20 ℃; for 7h; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/ol101658n

Reference yield: 94.0%

nitromethane (75-52-5) + 4-methoxy-benzaldehyde (123-11-5) → (S)-1-(4-methoxy-phenyl)-2-nitro-ethanol + (R)-1-(4-methoxyphenyl)-2-nitroethanol (675579-61-0)

Guidance literature:

With chiral copper-salen complex grafted over functionalized mesoporous silica; In dichloromethane; at 25 ℃; for 15h; enantioselective reaction; Catalytic behavior;

DOI:10.1039/c8nj01745j

Reference yield: 91.0%

(2R,6S)-2-[(R)-1-(4-Methoxy-phenyl)-2-nitro-ethoxy]-6-methyl-tetrahydro-pyran (675579-60-9) → (R)-1-(4-methoxyphenyl)-2-nitroethanol (675579-61-0)

Guidance literature:

With methanol; MP-TsOH;

DOI:10.1016/j.tetasy.2003.10.018

upstream raw materials:

(2R,6S)-2-[(R)-1-(4-Methoxy-phenyl)-2-nitro-ethoxy]-6-methyl-tetrahydro-pyran

1-(4-methoxy-phenyl)-2-nitro-ethanol

nitromethane

4-methoxy-benzaldehyde

Downstream raw materials:

(R)-(-)-2-Amino-1-(4-methoxyphenyl)-1-ethanol

(R)-(-)-N-(2-hydroxy-2-(4-methoxyphenyl)ethyl)benzamide