4-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-1-methyl-1H-benzimidazol-6-yloxymethyl}-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid

Base Information

Chemical Name:4-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-1-methyl-1H-benzimidazol-6-yloxymethyl}-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid
CAS No.:1350439-20-1
Molecular Formula:C₄₁H₃₇N₉O₆S
Molecular Weight:783.867
Hs Code.:

4-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-1-methyl-1H-benzimidazol-6-yloxymethyl}-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid

Synonyms:4-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-1-methyl-1H-benzimidazol-6-yloxymethyl}-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid

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Chemical Property of 4-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-1-methyl-1H-benzimidazol-6-yloxymethyl}-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid

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Technology Process of 4-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-1-methyl-1H-benzimidazol-6-yloxymethyl}-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid

There total 6 articles about 4-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-1-methyl-1H-benzimidazol-6-yloxymethyl}-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-1-methyl-1H-benzimidazol-6-yloxymethyl}-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid ethyl ester hydrochloride

: 1350439-20-1
4-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-1-methyl-1H-benzimidazol-6-yloxymethyl}-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid

Guidance literature:: With hydrogenchloride; acetic acid; In water; at 90 ℃; for 27h;

Reference yield:

: 299176-17-3
N-(2-nitro-5-chlorophenyl)-N-methylcarbamic acid t-butyl ester

: 1350439-20-1
4-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-1-methyl-1H-benzimidazol-6-yloxymethyl}-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.43 h / 20 °C / Cooling with ice

1.2: 24 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 6 h / 20 °C / Inert atmosphere

3.1: diethyl cyanophosphonate; triethylamine / tetrahydrofuran / 120 h / 20 °C

4.1: hydrogenchloride / ethanol; 1,4-dioxane / 78.5 h / 20 - 120 °C

5.1: acetic acid; hydrogenchloride / water / 27 h / 90 °C

With hydrogenchloride; diethyl cyanophosphonate; palladium 10% on activated carbon; hydrogen; sodium hydride; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1350440-17-3
4-(3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenoxymethyl)-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid ethyl ester

: 1350439-20-1
4-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-1-methyl-1H-benzimidazol-6-yloxymethyl}-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 6 h / 20 °C / Inert atmosphere

2: diethyl cyanophosphonate; triethylamine / tetrahydrofuran / 120 h / 20 °C

3: hydrogenchloride / ethanol; 1,4-dioxane / 78.5 h / 20 - 120 °C

4: acetic acid; hydrogenchloride / water / 27 h / 90 °C

With hydrogenchloride; diethyl cyanophosphonate; palladium 10% on activated carbon; hydrogen; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; water;