2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]prop-2-enoic acid

Base Information

Chemical Name:2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]prop-2-enoic acid
CAS No.:1259023-69-2
Molecular Formula:C₂₂H₁₇ClFN₃O₃
Molecular Weight:425.847
Hs Code.:

Synonyms:2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]prop-2-enoic acid

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Chemical Property of 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]prop-2-enoic acid

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Technology Process of 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]prop-2-enoic acid

There total 7 articles about 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]prop-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1259023-67-0
methyl 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]prop-2-enoate

: 1259023-69-2
2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]prop-2-enoic acid

Guidance literature:: methyl 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]prop-2-enoate; With potassium hydroxide; In tert-butyl alcohol; at 30 ℃; for 4h;

With water; citric acid; In tert-butyl alcohol; pH=5;

Reference yield:

: 1259022-73-5
6-(3-fluoro-4-hydroxyphenyl)-3,5-dimethylpyrazine-2-carboxamide

: 1259023-69-2
2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]prop-2-enoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / tetrahydrofuran / 120 °C

2: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; lithium chloride / 1,2-dimethoxyethane; water; methanol / 65 °C

3: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

4: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 20 °C

5: potassium hydroxide / tert-butyl alcohol / 20 °C

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; methanesulfonyl chloride; triethylamine; lithium chloride; potassium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1039/c2md20190a

Reference yield:

: 760990-08-7
2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

: 1259023-69-2
2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]prop-2-enoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: potassium phosphate / 1,2-dimethoxyethane; ethanol; water / 80 °C

2: potassium carbonate / tetrahydrofuran / 120 °C

3: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; lithium chloride / 1,2-dimethoxyethane; water; methanol / 65 °C

4: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

5: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 20 °C

6: potassium hydroxide / tert-butyl alcohol / 20 °C

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; methanesulfonyl chloride; triethylamine; lithium chloride; potassium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1039/c2md20190a