methyl 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]prop-2-enoate

Base Information

Chemical Name:methyl 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]prop-2-enoate
CAS No.:1259023-67-0
Molecular Formula:C₂₃H₁₉ClFN₃O₃
Molecular Weight:439.874
Hs Code.:

Synonyms:methyl 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]prop-2-enoate

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Chemical Property of methyl 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]prop-2-enoate

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Technology Process of methyl 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]prop-2-enoate

There total 6 articles about methyl 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1259023-65-8
methyl 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]-3-hydroxypropanoate

: 1259023-67-0
methyl 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]prop-2-enoate

Guidance literature:: With methanesulfonyl chloride; triethylamine; In tetrahydrofuran; at 20 ℃;
DOI:10.1039/c2md20190a

Reference yield:

: 760990-08-7
2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

: 1259023-67-0
methyl 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]prop-2-enoate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium phosphate / 1,2-dimethoxyethane; ethanol; water / 80 °C

2: potassium carbonate / tetrahydrofuran / 120 °C

3: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; lithium chloride / 1,2-dimethoxyethane; water; methanol / 65 °C

4: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

5: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 20 °C

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; methanesulfonyl chloride; triethylamine; lithium chloride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1039/c2md20190a

Reference yield:

: 1259022-73-5
6-(3-fluoro-4-hydroxyphenyl)-3,5-dimethylpyrazine-2-carboxamide

: 1259023-67-0
methyl 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]prop-2-enoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrahydrofuran / 120 °C

2: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; lithium chloride / 1,2-dimethoxyethane; water; methanol / 65 °C

3: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

4: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 20 °C

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; methanesulfonyl chloride; triethylamine; lithium chloride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c2md20190a