2-(2-{5-[3-(carboxymethyl)-5-[3-(trifluoromethoxy)phenyl]thiophen-2-yl]thiophen-2-yl}-5-[3-(trifluoromethoxy)phenyl]thiophen-3-yl)acetic acid

Base Information

Chemical Name:2-(2-{5-[3-(carboxymethyl)-5-[3-(trifluoromethoxy)phenyl]thiophen-2-yl]thiophen-2-yl}-5-[3-(trifluoromethoxy)phenyl]thiophen-3-yl)acetic acid
CAS No.:1419170-51-6
Molecular Formula:C₃₀H₁₈F₆O₆S₃
Molecular Weight:684.658
Hs Code.:

Synonyms:2-(2-{5-[3-(carboxymethyl)-5-[3-(trifluoromethoxy)phenyl]thiophen-2-yl]thiophen-2-yl}-5-[3-(trifluoromethoxy)phenyl]thiophen-3-yl)acetic acid

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Chemical Property of 2-(2-{5-[3-(carboxymethyl)-5-[3-(trifluoromethoxy)phenyl]thiophen-2-yl]thiophen-2-yl}-5-[3-(trifluoromethoxy)phenyl]thiophen-3-yl)acetic acid

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Technology Process of 2-(2-{5-[3-(carboxymethyl)-5-[3-(trifluoromethoxy)phenyl]thiophen-2-yl]thiophen-2-yl}-5-[3-(trifluoromethoxy)phenyl]thiophen-3-yl)acetic acid

There total 6 articles about 2-(2-{5-[3-(carboxymethyl)-5-[3-(trifluoromethoxy)phenyl]thiophen-2-yl]thiophen-2-yl}-5-[3-(trifluoromethoxy)phenyl]thiophen-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1419172-40-9
C₃₂H₂₂F₆O₆S₃

: 1419170-51-6
2-(2-{5-[3-(carboxymethyl)-5-[3-(trifluoromethoxy)phenyl]thiophen-2-yl]thiophen-2-yl}-5-[3-(trifluoromethoxy)phenyl]thiophen-3-yl)acetic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃;

Reference yield:

: 1419171-64-4
methyl 2-(5-bromo-2-{5-[5-bromo-3-(2-methoxy-2-oxoethyl)thiophen-2-yl]thiophen-2-yl}thiophen-3-yl)acetate

: 1419170-51-6
2-(2-{5-[3-(carboxymethyl)-5-[3-(trifluoromethoxy)phenyl]thiophen-2-yl]thiophen-2-yl}-5-[3-(trifluoromethoxy)phenyl]thiophen-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium fluoride / toluene; methanol / 3 h / 60 °C / Inert atmosphere

2: sodium hydroxide / 1,4-dioxane; water / 20 °C

With potassium fluoride; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; sodium hydroxide; In 1,4-dioxane; methanol; water; toluene; 1: |Suzuki Coupling;

Reference yield:

: 58414-52-1
thiophen-3-yl-acetic acid methyl ester

: 1419170-51-6
2-(2-{5-[3-(carboxymethyl)-5-[3-(trifluoromethoxy)phenyl]thiophen-2-yl]thiophen-2-yl}-5-[3-(trifluoromethoxy)phenyl]thiophen-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide; acetic acid / chloroform / 72 h / 0 - 20 °C

2: potassium carbonate; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride / toluene; methanol / 1.5 h / 50 °C / Inert atmosphere

3: N-Bromosuccinimide; acetic acid / 2 h / 20 °C

4: [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium fluoride / toluene; methanol / 3 h / 60 °C / Inert atmosphere

5: sodium hydroxide / 1,4-dioxane; water / 20 °C

With potassium fluoride; N-Bromosuccinimide; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium carbonate; acetic acid; sodium hydroxide; In 1,4-dioxane; methanol; chloroform; water; toluene; 2: |Suzuki Coupling / 4: |Suzuki Coupling;