58414-52-1

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
Methyl thiophene-3-acetate is used as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique chemical structure allows it to be a valuable component in the development of new drugs and agricultural products, contributing to advancements in these fields.
Used in Perfume and Fragrance Industry:
Methyl thiophene-3-acetate is used as a fragrance ingredient for its strong, sweet, and floral scent. It adds depth and complexity to perfumes and other fragranced products, enhancing their appeal and longevity.
Used in Food Industry:
As a flavoring agent, methyl thiophene-3-acetate is incorporated into the food industry to impart specific tastes and aromas to various food products. Its use in this industry is regulated to ensure safety and quality standards are met.

InChI:InChI=1/C7H8O2S/c1-9-7(8)4-6-2-3-10-5-6/h2-3,5H,4H2,1H3

Upstream product

• 67-56-1 methanol 
• 13781-65-2 2-(thiophen-3-yl)acetyl chloride 
• 6964-21-2 thiophen-3-yl-acetic acid 
• 872-31-1 3-Bromothiophene 
• 96-34-4 methyl chloroacetate 
• 79-22-1 methyl chloroformate 
• 32766-64-6 ethyl 2,5-dichloro-3-thienylglyoxylate 
• 124687-94-1 1-diazo-2-(thiophen-3-yl)ethanone 
• 67237-53-0 3-ethynylthiophene 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 34967-61-8 2,5-dichlorothienylacetic acid 
• 95461-18-0 methyl 2,5-dichloro-3-thienylacetate 

Downstream Products

• 70158-52-0 dimethyl 3-thienylmalonate 
• 1584151-38-1 tert-butyl(3-(2-(methylthio)-7-oxo-6-(thiophen-3-yl)pyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)carbamate 
• 1419172-12-5 C₄₆H₃₈O₈S₄ 
• 1419170-05-0 2-(5-{3-[4-(carboxymethyl)-5-{4-[3-(carboxymethyl)thiophen-2-yl]phenyl}thiophen-2-yl]phenyl}-2-{4-[3-(carboxymethyl)thiophen-2-yl]phenyl}thiophen-3-yl)acetic acid 
• 1419172-13-6 C₄₆H₃₈O₈S₄ 
• 1419170-04-9 2-(2-{4-[3-(carboxymethyl)-5-{4-[4-(carboxymethyl)-5-{4-[3-(carboxymethyl)thiophen-2-yl]phenyl}thiophen-2-yl]phenyl}thiophen-2-yl]phenyl}thiophen-3-yl)acetic acid 
• 1419170-03-8 2-(5-{4-[4-(carboxymethyl)-5-(4-methanesulfonylphenyl)thiophen-2-yl]phenyl}-2-(4-methanesulfonylphenyl)thiophen-3-yl)acetic acid 
• 1419172-11-4 C₃₄H₃₀O₈S₄ 
• 1419170-02-7 2-(5-{5-[4-(carboxymethyl)-5-(4-methanesulfonylphenyl)thiophen-2-yl]thiophen-2-yl}-2-(4-methanesulfonylphenyl)thiophen-3-yl)acetic acid 
• 1419172-10-3 C₃₂H₂₈O₈S₅ 
• 1419169-99-5 2-(2-{5-[3-(carboxymethyl)-5-{3-[4-(carboxymethyl)-5-{5-[3-(carboxymethyl)thiophen-2-yl]thiophen-2-yl}thiophen-2-yl]phenyl}thiophen-2-yl]thiophen-2-yl}thiophen-3-yl)acetic acid 
• 1419172-09-0 C₄₂H₃₄O₈S₆ 
• 1419172-07-8 C₄₂H₃₄O₈S₆ 
• 1419169-98-4 2-(2-{5-[3-(carboxymethyl)-5-{4-[4-(carboxymethyl)-5-{5-[3-(carboxymethyl)thiophen-2-yl]thiophen-2-yl}thiophen-2-yl]phenyl}thiophen-2-yl]thiophen-2-yl}thiophen-3-yl)acetic acid 

Relevant academic research and scientific papers

Synthesis and characterization of poly(3-thiophene acetic acid)/Fe 3O4 nanocomposite

Poly(3-thiophene acetic acid)/Fe3O4 nanocomposite is synthesized by the precipitation of Fe3O4 in the presence of poly(3-thiophene acetic acid) (P3TAA). Structural, surface, morphological, thermal properties and conductivity characterization/evaluation of the nanocomposite were performed by XRD, FT-IR, TEM, TGA, and conductivity measurements, respectively. The capping of P3TAA around Fe3O 4 nanoparticles was confirmed by FT-IR spectroscopy, the interaction being via bridging oxygens of the carboxylate and the nanoparticle surface through bidentate binding. The crystallite and particle size were obtained as 9 ± 2 nm and 11 ± 1 nm from XRD line profile fitting and TEM image analysis, respectively, which reveal nearly single crystalline nature of Fe 3O4 nanoparticles. Magnetization measurements reveal that P3TAA coated magnetite particles do not saturate at higher fields. There is no coercivity and remanence revealing superparamagnetic character. Magnetic particle size calculated from the theoretical fitting as 9.1 nm which coincides the values determined from TEM micrographs and XRD line profile fitting. The comparison to the TEM particle size reveals slightly modified magnetically dead nanoparticle surface.

Synthesis of functionalized thiophenes for the preparation of conducting polymer films with complexing properties

Four series of novel substituted thiophenes (Schiff bases, esters, amides, and amino acids) have been synthesized and tested for their ability to form conducting polymer films via cyclic voltammetry in order to obtain electrochemical sensors for metal cations. The influence of the nature and size of the substituents on the electropolymerizability of the monomers has been studied. Copyright Taylor & Francis Group, LLC.

Preparation and electrochemical performance of TEMPO-modified polyterthiophene electrode obtained by electropolymerization

A novel monomer of terthiophene with a side chain TEMPO, 4-(2,5-di(thiophen-2-yl)thiophen-3-yl)acetyl-oxy-2,2,6,6-tetramethylpiperidin-1-yloxy (TT-TEMPO) was successfully synthesized. Its corresponding polymer PTT-TEMPO was prepared via electrochemical polymerization on Pt electrode in boron trifluoride diethyl etherate solution. PTT-TEMPO film showed a uniform network structure. Compared with bare Pt electrode, PTT-TEMPO electrode exhibited high electrocatalytic performance for oxidation of benzyl alcohol in the presence of 2,6-lutidine under similar conditions. Benzyl alcohol was selectively oxidized to benzaldehyde based on in situ FTIR analysis.

syn-Selective Michael Reaction of α-Branched Aryl Acetaldehydes with Nitroolefins Promoted by Squaric Amino Acid Derived Bifunctional Br?nsted Bases

Here we describe a direct access to 2,2,3-trisubstituted syn γ-nitroaldehydes by addition of α-branched aryl acetaldehydes to nitroolefins promoted by a cinchona based squaric acid-derived amino acid peptide. Different α-methyl arylacetaldehydes react with β-aromatic and β-alkyl nitroolefins to afford the Michael adducts in high enantioselectivity and syn-selectivity. NMR experiments and DFT calculations predict the reaction to occur through the intermediacy of E-enolate. The interaction between the substrates and the catalyst follows Pápai's model, wherein an intramolecular H-bond interaction in the catalyst between the NH group of one of the tert-leucines and the squaramide oxygen seems to be key for discrimination of the corresponding reaction transition states.

Green Esterification of Carboxylic Acids Promoted by tert-Butyl Nitrite

In this work, the green esterification of carboxylic acids promoted by tert-butyl nitrite has been well developed. This transformation is compatible with a broad range of substrates and exhibits excellent functional group tolerance. Various drugs and substituted amino acids are applicable to this reaction under near neutral conditions, with good to excellent yields.

SULFONAMIDE DERIVATIVES AND USES THEREOF

The present disclosure relates to compounds of Formula (I) or (II): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.

AMINO-BENZOISOTHIAZOLE AND AMINO-BENZOISOTHIADIAZOLE AMIDE COMPOUNDS

Provided herein are amino-benzoisothiazole and benzoisothiadiazole amide compounds. In particular, provided herein are compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds provided herein are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, retinal diseases such as acute macular degeneration (AMD) and diabetic macular edema (DME), diseases and conditions characterized by inflammatory processes, cardiovascular diseases, and diseases characterized by abnormal growth, such as cancers. Also provided are compositions (e.g., pharmaceutical compositions) comprising the compounds provided herein.

HETEROCYCLIC COMPOUNDS

The present invention relates to compounds of the general formula (1) wherein the variables are defined as given in the description and claims. The invention further relates to uses of and to, processes and intermediates related to compounds of the general formula (I), wherein Q is wherein the substituents of I, Ia and Ib are as defined in description and claims.

EZH2 Inhibitors

The present invention relates to compounds that inhibit EZH2 activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.

Interface engineering of hybrid perovskite solar cells with poly(3-thiophene acetic acid) under ambient conditions

The properties of methyl ammonium lead iodide (MAPbI3) perovskite solar cells with poly(3-thiophene acetic acid) (P3TAA) as a hole transporting material (HTM) and a dense layer of ZnO nanoparticle film as an electron transporting material (ETM) are described using the conventional ZnO (n)/perovskite (i)/P3TAA (p) (n-i-p) architecture. The FT-IR spectra of a MAPbI3/P3TAA mixture indicate a shift of the N-H stretching and the abolition of the N-H bending peak indicating the interaction between the components. UV-Vis spectra of the mixture exhibit a large red shift of the π-π? transition peak of the conjugated chain arising from the interaction causing an increase of the conjugation length. The cross-sectional SEM image of the device shows the sequence of the individual layers of ZnO, MAPbI3, P3TAA and Ag, respectively. The current density (J)-voltage (V) curves obtained upon illumination with a light of 100 mW cm-2 indicate the average PCE to be 7.38 ± 0.59% under ambient conditions. The IPCE values of these cells reach about 63% across a broad range of wavelength (300-800 nm). The HOMO and the LUMO of P3TAA are measured using cyclic voltammetry and the optical band gap and the relative energy level of the components explain the operation of photocurrent in the cell. For comparison purposes a device using poly(3-hexyl thiophene) (P3HT) as the HTM is fabricated under similar conditions and it exhibits a lower PCE (5.85 ± 0.51%) than that of the P3TAA based device. The longevity of the P3TAA based cell is also found to be better than that of the P3HT based cell for storing in air. The UV-Vis and impedance spectral results clearly explain the above results, signifying the influence of the interface on the performance of hybrid solar cells.