(S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]indan-1-ylamine

Base Information

Chemical Name:(S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]indan-1-ylamine
CAS No.:1392072-78-4
Molecular Formula:C₁₈H₁₅ClFN₃O
Molecular Weight:343.788
Hs Code.:

Synonyms:(S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]indan-1-ylamine

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Chemical Property of (S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]indan-1-ylamine

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Technology Process of (S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]indan-1-ylamine

There total 1 articles about (S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]indan-1-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1392072-81-9
{(S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]indan-1-yl}carbamic acid tert-butyl ester

: 1392072-78-4
(S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]indan-1-ylamine

Guidance literature:: In tetrahydrofuran; dichloromethane; water; at 20 ℃; for 25h; Inert atmosphere;

Reference yield: 100.0%

: 1380327-56-9
3-(9H-fluoren-9-ylmethoxycarbonylamino)oxetane-3-carboxylic acid

: 1392072-78-4
(S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]indan-1-ylamine

: 1392072-85-3
(3-{(S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]indan-1-ylcarbamoyl}oxetan-3-yl)carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: 3-(9H-fluoren-9-ylmethoxycarbonylamino)oxetane-3-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

(S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]indan-1-ylamine; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

: 1392072-78-4
(S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]indan-1-ylamine

: 1392074-06-4
3-aminooxetane-3-carboxylic acid {(S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]indan-1-yl}amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-hydroxy-1H-benzotriazol hydrate / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

1.2: 20 h / 20 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: piperidine / dichloromethane / 15 h / 20 °C / Inert atmosphere

With piperidine; 1-hydroxy-1H-benzotriazol hydrate; In dichloromethane; N,N-dimethyl-formamide;