(3-{(S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]indan-1-ylcarbamoyl}oxetan-3-yl)carbamic acid 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:(3-{(S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]indan-1-ylcarbamoyl}oxetan-3-yl)carbamic acid 9H-fluoren-9-ylmethyl ester
CAS No.:1392072-85-3
Molecular Formula:C₃₇H₃₀ClFN₄O₅
Molecular Weight:665.12
Hs Code.:

Synonyms:(3-{(S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]indan-1-ylcarbamoyl}oxetan-3-yl)carbamic acid 9H-fluoren-9-ylmethyl ester

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Chemical Property of (3-{(S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]indan-1-ylcarbamoyl}oxetan-3-yl)carbamic acid 9H-fluoren-9-ylmethyl ester

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Technology Process of (3-{(S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]indan-1-ylcarbamoyl}oxetan-3-yl)carbamic acid 9H-fluoren-9-ylmethyl ester

There total 3 articles about (3-{(S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]indan-1-ylcarbamoyl}oxetan-3-yl)carbamic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1380327-56-9
3-(9H-fluoren-9-ylmethoxycarbonylamino)oxetane-3-carboxylic acid

: 1392072-78-4
(S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]indan-1-ylamine

: 1392072-85-3
(3-{(S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]indan-1-ylcarbamoyl}oxetan-3-yl)carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: 3-(9H-fluoren-9-ylmethoxycarbonylamino)oxetane-3-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

(S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]indan-1-ylamine; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 1392072-85-3
(3-{(S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]indan-1-ylcarbamoyl}oxetan-3-yl)carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / 1,4-dioxane; water / 1.25 h / 20 °C / Inert atmosphere

2.1: 1-hydroxy-1H-benzotriazol hydrate / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

2.2: 20 h / 20 °C / Inert atmosphere

2.3: Inert atmosphere

With 1-hydroxy-1H-benzotriazol hydrate; potassium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 1392072-81-9
{(S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]indan-1-yl}carbamic acid tert-butyl ester

: 1392072-85-3
(3-{(S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]indan-1-ylcarbamoyl}oxetan-3-yl)carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane; water; tetrahydrofuran / 25 h / 20 °C / Inert atmosphere

2.1: 1-hydroxy-1H-benzotriazol hydrate / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

2.2: 20 h / 20 °C / Inert atmosphere

2.3: Inert atmosphere

With 1-hydroxy-1H-benzotriazol hydrate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;