6-benzyl-4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine

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Chemical Name:6-benzyl-4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine
CAS No.:1383376-97-3
Molecular Formula:C₂₄H₂₁FN₄
Molecular Weight:384.456
Hs Code.:

Synonyms:6-benzyl-4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine

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Chemical Property of 6-benzyl-4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine

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Technology Process of 6-benzyl-4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine

There total 10 articles about 6-benzyl-4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383376-96-2
6-benzyl-4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one

: 1383376-97-3
6-benzyl-4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1286230-78-1
3-(4-fluorophenyl)-1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1383376-97-3
6-benzyl-4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / N,N-dimethyl-formamide / 20 - 50 °C / Inert atmosphere

2.1: dimethyl sulfoxide / 2 h / 50 °C

3.1: potassium hydroxide; water / 24 h / 100 °C

4.1: acetic anhydride; acetic acid / 3 h / 110 °C

5.1: acetic acid / 18 h / Reflux

6.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0.5 h / 20 °C

6.2: 40 °C

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; water; acetic anhydride; caesium carbonate; acetic acid; potassium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1383377-50-1
3-fluoro-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-picolinonitrile

: 1383376-97-3
6-benzyl-4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: dimethyl sulfoxide / 2 h / 50 °C

2.1: potassium hydroxide; water / 24 h / 100 °C

3.1: acetic anhydride; acetic acid / 3 h / 110 °C

4.1: acetic acid / 18 h / Reflux

5.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0.5 h / 20 °C

5.2: 40 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

With lithium aluminium tetrahydride; boron trifluoride diethyl etherate; water; acetic anhydride; acetic acid; potassium hydroxide; In tetrahydrofuran; dimethyl sulfoxide;