3-fluoro-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-picolinonitrile

Base Information

Chemical Name:3-fluoro-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-picolinonitrile
CAS No.:1383377-50-1
Molecular Formula:C₁₆H₁₀F₂N₄
Molecular Weight:296.279
Hs Code.:

Synonyms:3-fluoro-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-picolinonitrile

Suppliers and Price of 3-fluoro-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-picolinonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemicals and raw materials
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Total 3 raw suppliers

Chemical Property of 3-fluoro-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-picolinonitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of 3-fluoro-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-picolinonitrile

There total 10 articles about 3-fluoro-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-picolinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 669066-35-7
3-fluoro-4-iodo-2-pyridinecarbonitrile

: 1286230-78-1
3-(4-fluorophenyl)-1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1383377-50-1
3-fluoro-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-picolinonitrile

Guidance literature:: With tetrabutylammomium bromide; palladium diacetate; 1,3-bis(mesityl)imidazolium chloride; triethylamine; In water; acetonitrile; for 4h; Reagent/catalyst; Catalytic behavior; Reflux; Inert atmosphere;
DOI:10.1080/00397911.2020.1791341

Reference yield: 55.0%

: 7677-24-9
trimethylsilyl cyanide

: 1383377-58-9
3-fluoro-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridine 1-oxide

: 1383377-50-1
3-fluoro-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-picolinonitrile

Guidance literature:: With triethylamine; In acetonitrile; at 70 ℃; for 96h;

Reference yield:

: 863605-34-9
4-bromo-3-(4-fluorophenyl)-1-methyl-1H-pyrazole

: 1383377-50-1
3-fluoro-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-picolinonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 3 h / 20 - 25 °C

1.2: 10 - 20 °C

1.3: 10 - 25 °C

2.1: caesium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / N,N-dimethyl-formamide / 20 - 50 °C / Inert atmosphere

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; isopropylmagnesium chloride; caesium carbonate; lithium chloride; In tetrahydrofuran; N,N-dimethyl-formamide;