(S)-1-[3,5-O-(2-benzyloxycarbonylamino-1-diethylphosphonoethylidene)-2-deoxy-β-D-threo-pentofuranosyl]thymine

Base Information

• Chemical Name: (S)-1-[3,5-O-(2-benzyloxycarbonylamino-1-diethylphosphonoethylidene)-2-deoxy-β-D-threo-pentofuranosyl]thymine
• CAS No.: 183115-56-2
• Molecular Formula: C₂₄H₃₂N₃O₁₀P
• Molecular Weight: 553.506
• Mol file: 183115-56-2.mol

Synonyms:(S)-1-[3,5-O-(2-benzyloxycarbonylamino-1-diethylphosphonoethylidene)-2-deoxy-β-D-threo-pentofuranosyl]thymine

Chemical Property of (S)-1-[3,5-O-(2-benzyloxycarbonylamino-1-diethylphosphonoethylidene)-2-deoxy-β-D-threo-pentofuranosyl]thymine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-[3,5-O-(2-benzyloxycarbonylamino-1-diethylphosphonoethylidene)-2-deoxy-β-D-threo-pentofuranosyl]thymine

There total 4 articles about (S)-1-[3,5-O-(2-benzyloxycarbonylamino-1-diethylphosphonoethylidene)-2-deoxy-β-D-threo-pentofuranosyl]thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

diethyl phosphorylchloridite (589-57-1) + (R)-1-[3,5-O-(2-benzyloxycarbonylamino-1-ethoxyethylidene)-2-deoxy-β-D-threo-pentofuranosyl]thymine (214046-41-0) → (S)-1-[3,5-O-(2-benzyloxycarbonylamino-1-diethylphosphonoethylidene)-2-deoxy-β-D-threo-pentofuranosyl]thymine (183115-56-2)

Guidance literature:

In acetonitrile; at -40 - 0 ℃;

DOI:10.1016/S0040-4020(98)00654-1

Reference yield: 88.0%

diethyl chlorophosphate (814-49-3) + [(4aR,6R,7aR)-2-Ethoxy-6-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furo[3,2-d][1,3]dioxin-2-ylmethyl]-carbamic acid benzyl ester → (S)-1-[3,5-O-(2-benzyloxycarbonylamino-1-diethylphosphonoethylidene)-2-deoxy-β-D-threo-pentofuranosyl]thymine (183115-56-2)

Guidance literature:

at -40 - 0 ℃;

Reference yield:

ethyl N-benzyloxycarbonylamino-orthoacetate (13347-35-8) → (S)-1-[3,5-O-(2-benzyloxycarbonylamino-1-diethylphosphonoethylidene)-2-deoxy-β-D-threo-pentofuranosyl]thymine (183115-56-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / 12 M HCl / dimethylformamide; CH₂Cl₂ / 0 °C / pH 15

2: 88 percent / acetonitrile / -40 - 0 °C

With hydrogenchloride; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1: Substitution / 2: Substitution;

DOI:10.1016/S0040-4020(98)00654-1

upstream raw materials:

diethyl chlorophosphate

diethyl phosphorylchloridite

(R)-1-[3,5-O-(2-benzyloxycarbonylamino-1-ethoxyethylidene)-2-deoxy-β-D-threo-pentofuranosyl]thymine

ethyl N-benzyloxycarbonylamino-orthoacetate