bis(4-fluorophenyl)(2-nitro-1-phenylethyl)phosphine oxide

Base Information

• Chemical Name: bis(4-fluorophenyl)(2-nitro-1-phenylethyl)phosphine oxide
• CAS No.: 1003879-43-3
• Molecular Formula: C₂₀H₁₆F₂NO₃P
• Molecular Weight: 387.323
• Mol file: 1003879-43-3.mol

Synonyms:bis(4-fluorophenyl)(2-nitro-1-phenylethyl)phosphine oxide

Chemical Property of bis(4-fluorophenyl)(2-nitro-1-phenylethyl)phosphine oxide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of bis(4-fluorophenyl)(2-nitro-1-phenylethyl)phosphine oxide

There total 3 articles about bis(4-fluorophenyl)(2-nitro-1-phenylethyl)phosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-nitroethenyl)benzene (102-96-5) + bis(4-fluorophenyl)phosphane (25186-17-8) → bis(4-fluorophenyl)(2-nitro-1-phenylethyl)phosphine oxide + bis(4-fluorophenyl)(2-nitro-1-phenylethyl)phosphine oxide (1003879-43-3)

Guidance literature:

bis(p-fluorophenyl)phosphine; With (S,S)-2,6-bis((tert-butylmethylphosphino)methylene)-3,5-dimethylphenylpalladium(II) acetate; In dichloromethane; at -40 ℃; for 0.0833333h;

(2-nitroethenyl)benzene; With dihydrogen peroxide; In dichloromethane; water; at -40 - 20 ℃; for 3h; Overall yield = 88 %; Optical yield = 65 %ee; stereoselective reaction;

Reference yield:

nitrostyrene (5153-67-3) + bis(4-fluorophenyl)phosphine oxide (94940-35-9) → bis(4-fluorophenyl)(2-nitro-1-phenylethyl)phosphine oxide + bis(4-fluorophenyl)(2-nitro-1-phenylethyl)phosphine oxide (1003879-43-3)

Guidance literature:

chiral bicyclic guanidine; In diethyl ether; at 0 ℃; for 14h;

DOI:10.1039/b713151h

Reference yield:

nitrostyrene (5153-67-3) + bis(4-fluorophenyl)phosphane (25186-17-8) → bis(4-fluorophenyl)(2-nitro-1-phenylethyl)phosphine oxide + bis(4-fluorophenyl)(2-nitro-1-phenylethyl)phosphine oxide (1003879-43-3)

Guidance literature:

nitrostyrene; bis(p-fluorophenyl)phosphine; With acetoxy(2,6-bis(((S)-tert-butyl(methyl)phosphino)methyl)-3,5-dimethylphenyl)palladium(II); In dichloromethane; at -40 ℃; for 3h;

With dihydrogen peroxide; In dichloromethane; water; at 20 ℃; for 2h; Overall yield = 88 %; enantioselective reaction;

DOI:10.1021/ol402627f

upstream raw materials:

nitrostyrene

bis(4-fluorophenyl)phosphine oxide

bis(4-fluorophenyl)phosphane

(2-nitroethenyl)benzene