Bis(4-fluorophenyl)phosphine oxide

Base Information

Chemical Name:Bis(4-fluorophenyl)phosphine oxide
CAS No.:94940-35-9
Molecular Formula:C12H9F2OP
Molecular Weight:238.173
Hs Code.:
DSSTox Substance ID:DTXSID10537195
Wikidata:Q82412115

Synonyms:bis(4-fluorophenyl)phosphine oxide;94940-35-9;Phosphine oxide, bis(4-fluorophenyl)-;bis(4-fluorophenyl)-oxophosphanium;SCHEMBL1305285;bis(4-fluorophenyl)phosphineoxide;DTXSID10537195;WMQXKXZCFOGSFU-UHFFFAOYSA-N;Bis(4-fluorophenyl)(oxo)phosphanium;bis(4-fluorophenyl)-Phosphine oxide;CS-0098794;E81179;1-fluoro-4-[(4-fluorophenyl)phosphoroso]benzene

Suppliers and Price of Bis(4-fluorophenyl)phosphine oxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 12 raw suppliers

Chemical Property of Bis(4-fluorophenyl)phosphine oxide

Chemical Property:

Boiling Point:320.6±52.0 °C(Predicted)
PSA：51.21000
LogP:2.74300
XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:237.02808320
Heavy Atom Count:16
Complexity:219

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1F)[P+](=O)C2=CC=C(C=C2)F

Technology Process of Bis(4-fluorophenyl)phosphine oxide

There total 7 articles about Bis(4-fluorophenyl)phosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 352-13-6
4-flourophenylmagnesium bromide

: 94940-35-9
bis(4-fluorophenyl)phosphine oxide

Guidance literature:: With phosphonic acid diethyl ester; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.3762/BJOC.16.164

Reference yield: 96.0%

: 460-00-4
1-Bromo-4-fluorobenzene

: 94940-35-9
bis(4-fluorophenyl)phosphine oxide

Guidance literature:: 1-Bromo-4-fluorobenzene; With magnesium; In tetrahydrofuran; at 20 ℃; for 2h;

With phosphonic acid diethyl ester; In tetrahydrofuran;
DOI:10.1021/acs.orglett.9b00569

Reference yield: 70.0%

: 762-04-9
phosphonic acid diethyl ester

: 460-00-4
1-Bromo-4-fluorobenzene

: 94940-35-9
bis(4-fluorophenyl)phosphine oxide

Guidance literature:: 1-Bromo-4-fluorobenzene; With iodine; magnesium; In tetrahydrofuran; at 0 - 40 ℃; for 2.16667h; Inert atmosphere;

phosphonic acid diethyl ester; In tetrahydrofuran; at 20 - 25 ℃; for 15.5h; Inert atmosphere;
DOI:10.1246/bcsj.20210023