5-bromo-pyrimidine-2-carboxylic acid [3-((R)-5-amino-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-5-bromo-phenyl]-amide hydrochloride

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Chemical Name:5-bromo-pyrimidine-2-carboxylic acid [3-((R)-5-amino-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-5-bromo-phenyl]-amide hydrochloride
CAS No.:1262855-75-3
Molecular Formula:C₁₆H₁₅Br₂N₅O₂*ClH
Molecular Weight:505.596
Hs Code.:

Synonyms:5-bromo-pyrimidine-2-carboxylic acid [3-((R)-5-amino-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-5-bromo-phenyl]-amide hydrochloride

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Chemical Property of 5-bromo-pyrimidine-2-carboxylic acid [3-((R)-5-amino-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-5-bromo-phenyl]-amide hydrochloride

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Technology Process of 5-bromo-pyrimidine-2-carboxylic acid [3-((R)-5-amino-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-5-bromo-phenyl]-amide hydrochloride

There total 14 articles about 5-bromo-pyrimidine-2-carboxylic acid [3-((R)-5-amino-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-5-bromo-phenyl]-amide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262859-31-3
((R)-5-{3-bromo-5-[(5-bromo-pyrimidine-2-carbonyl)-amino]-phenyl}-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)-carbamic acid tert-butyl ester

: 1262855-75-3
5-bromo-pyrimidine-2-carboxylic acid [3-((R)-5-amino-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-5-bromo-phenyl]-amide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 40 ℃; for 24h;

Reference yield:

: 127413-59-6
1-(3-bromo-5-nitrophenyl)ethanone

: 1262855-75-3
5-bromo-pyrimidine-2-carboxylic acid [3-((R)-5-amino-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-5-bromo-phenyl]-amide hydrochloride

Guidance literature:: Multi-step reaction with 12 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 2.5 h / Reflux

1.2: Cooling with ice

2.1: cesium fluoride / tetrahydrofuran; hexane / 4 h / -50 - 0 °C

3.1: hydrogenchloride / toluene / 4 h / Reflux

4.1: diborane / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

5.1: potassium carbonate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 19 h / 0 °C / Inert atmosphere

6.1: potassium tert-butylate / tert-butyl alcohol / 0.5 h / 100 °C / Inert atmosphere

7.1: Lawessons reagent / 2 h / 80 °C

8.1: tert.-butylhydroperoxide; ammonium hydroxide; ammonia / methanol / 2 h / 20 °C

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

10.1: hydrogen / Raney-Ni / methanol / 20 h / 1.5 °C

11.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 17 h / 0 - 20 °C / Inert atmosphere

12.1: hydrogenchloride / 1,4-dioxane / 24 h / 40 °C / Sealed vial

With Lawessons reagent; hydrogenchloride; tert.-butylhydroperoxide; ammonium hydroxide; potassium tert-butylate; ammonia; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; cesium fluoride; diborane; titanium(IV) tetraethanolate; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

: 355134-13-3
3-bromo-5-nitrobenzaldehyde

: 1262855-75-3
5-bromo-pyrimidine-2-carboxylic acid [3-((R)-5-amino-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-5-bromo-phenyl]-amide hydrochloride

Guidance literature:: Multi-step reaction with 14 steps

1.1: titanium tetrachloride / tetrahydrofuran; dichloromethane / 1 h / -78 - -30 °C

2.1: manganese(IV) oxide / 1,4-dioxane / 17 h / Reflux

3.1: titanium(IV) tetraethanolate / tetrahydrofuran / 2.5 h / Reflux

3.2: Cooling with ice

4.1: cesium fluoride / tetrahydrofuran; hexane / 4 h / -50 - 0 °C

5.1: hydrogenchloride / toluene / 4 h / Reflux

6.1: diborane / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

7.1: potassium carbonate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 19 h / 0 °C / Inert atmosphere

8.1: potassium tert-butylate / tert-butyl alcohol / 0.5 h / 100 °C / Inert atmosphere

9.1: Lawessons reagent / 2 h / 80 °C

10.1: tert.-butylhydroperoxide; ammonium hydroxide; ammonia / methanol / 2 h / 20 °C

11.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

12.1: hydrogen / Raney-Ni / methanol / 20 h / 1.5 °C

13.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 17 h / 0 - 20 °C / Inert atmosphere

14.1: hydrogenchloride / 1,4-dioxane / 24 h / 40 °C / Sealed vial

With Lawessons reagent; hydrogenchloride; tert.-butylhydroperoxide; manganese(IV) oxide; ammonium hydroxide; potassium tert-butylate; ammonia; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; cesium fluoride; diborane; titanium(IV) tetraethanolate; titanium tetrachloride; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;