355134-13-3

Basic information

• Product Name: 3-BROMO-5-NITROBENZALDEHYDE
• Synonyms: 3-BROMO-5-NITROBENZALDEHYDE;3-Fluoro-5-nitrobenzaldehyde;3-BroMo-5-nitrobenzaldehyde, 97+%;3-Bromo-5-formylnitrobenzene;Benzaldehyde,3-bromo-5-nitro-
• CAS NO: 355134-13-3
• Molecular Formula: C₇H₄BrNO₃
• Molecular Weight: 230.02
• Product Categories: Nitro CompoundsChemical Synthesis;Aldehydes;C7Organic Building Blocks;Carbonyl Compounds;New Products for Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 355134-13-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 101-106 °C
• Boiling Point: 306.9 °C at 760 mmHg
• Flash Point: 139.4 °C
• Appearance: Pale brown/Powder
• Density: 1.781
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: soluble in Methanol
• CAS DataBase Reference: 3-BROMO-5-NITROBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-5-NITROBENZALDEHYDE(355134-13-3)
• EPA Substance Registry System: 3-BROMO-5-NITROBENZALDEHYDE(355134-13-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38-43
• Safety Statements: 26-36/37
• WGK Germany: 3
• Hazardous Substances Data: 355134-13-3(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 72, p. 5867, 2007 DOI: 10.1021/jo070477u

Upstream product

• 139194-79-9 (3-bromo-5-nitrophenyl)methanol 
• 99-61-6 3-nitro-benzaldehyde 

Downstream Products

• 355133-17-4 N-[3-bromo-5-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide 
• 199177-26-9 3-bromo-5-hydroxybenzaldehyde 
• 936844-36-9 C₆₉H₇₈O₁₉ 
• 936844-26-7 ({3-(1,3-dioxolan-2-yl)-5-[(triisopropylsilyl)ethynyl]phenyl}ethynyl)(trimethyl)silane 
• 936844-22-3 [(3-(1,3-dioxolan-2-yl)-5-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}phenyl)ethynyl]-(trimethyl)silane 
• 936844-23-4 2-(3-ethynyl-5-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}phenyl)-1,3-dioxolane 
• 936844-21-2 2-(3-bromo-5-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}phenyl)-1,3-dioxolane 
• 936844-25-6 {[3-bromo-5-(1,3-dioxolan-2-yl)phenyl]ethynyl}(triisopropyl)silane 
• 936844-20-1 3-bromo-5-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}benzaldehyde 
• 936844-24-5 2-(3-bromo-5-iodophenyl)-1,3-dioxolane 
• 909854-23-5 3-bromo-5-[1,3]dioxolan-2-yl-phenol 
• 936844-19-8 3-bromo-5-(1,3-dioxolan-2-yl)aniline 
• 936844-18-7 2-(3-bromo-5-nitrophenyl)-1,3-dioxolane 
• 6307-83-1 3-bromo-5-nitro-benzoic acid 

Relevant articles and documents

Mild Darzens Annulations for the Assembly of Trifluoromethylthiolated (SCF3) Aziridine and Cyclopropane Structures

We report mild new annulation approaches to trisubstituted trifluoromethylthiolated (SCF3) aziridines and cyclopropanes via Darzens inspired protocols. The products of these anionic annulations, rarely studied previously, possess attractive features rendering them valuable building blocks for synthesis platforms. In this study, trisubstituted acetophenone nucleophiles bearing SCF3 and bromine substituents in their α position were shown to undergo [2 + 1] annulations with vinyl ketones and tosyl-protected imines under mild reaction conditions.

Synthesis and biological evaluation of GPR40/FFAR1 agonists containing 3,5-dimethylisoxazole

GPR40 is an attractive target due to its glucose-stimulated insulin secretion effect with low risk of causing hypoglycemia, which also can be seen from the clinical studies using TAK-875 (fasiglifam). In the present studies, we discovered a series of anal

2 -ARYLAMINOQUINAZOLINES FOR TREATING PROLIFERATIVE DISEASES

The invention provides novel compounds that are inhibitors of PDKI. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or composition.