4-(2-Bromo-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(2-oxo-propyl) ester

Base Information

• Chemical Name: 4-(2-Bromo-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(2-oxo-propyl) ester
• CAS No.: 99880-12-3
• Molecular Formula: C₁₉H₂₀BrNO₅
• Molecular Weight: 422.276

Synonyms:4-(2-Bromo-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(2-oxo-propyl) ester

Chemical Property of 4-(2-Bromo-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(2-oxo-propyl) ester

Chemical Property:

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Technology Process of 4-(2-Bromo-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(2-oxo-propyl) ester

There total 6 articles about 4-(2-Bromo-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(2-oxo-propyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-(2-Bromo-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(2-methyl-[1,3]dioxolan-2-ylmethyl) ester (103785-55-3) → 4-(2-Bromo-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(2-oxo-propyl) ester (99880-12-3)

Guidance literature:

With methanesulfonic acid; water; In ethanol; for 6h; Heating;

DOI:10.1248/cpb.34.1589

Reference yield:

acetoacetic acid methyl ester (105-45-3) → 4-(2-Bromo-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(2-oxo-propyl) ester (99880-12-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / AcOH, piperidine / benzene / 4 h / Ambient temperature

2: 51 percent / ethanol / Heating

3: 93 percent / MeSO₃H, H₂O / ethanol / 6 h / Heating

With piperidine; methanesulfonic acid; water; acetic acid; In ethanol; benzene;

DOI:10.1248/cpb.34.1589

Reference yield:

3-amino-2-crotonic acid 2,2-ethylenedioxy propyl ester (86780-81-6) → 4-(2-Bromo-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(2-oxo-propyl) ester (99880-12-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / ethanol / Heating

2: 93 percent / MeSO₃H, H₂O / ethanol / 6 h / Heating

With methanesulfonic acid; water; In ethanol;

DOI:10.1248/cpb.34.1589

upstream raw materials:

4-(2-Bromo-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(2-methyl-[1,3]dioxolan-2-ylmethyl) ester

acetoacetic acid methyl ester

3-amino-2-crotonic acid 2,2-ethylenedioxy propyl ester

2,2-ethylenedioxypropyl acetoacetate

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