3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-((2S,3R)-3-(tert-butyldimethylsilyloxy)butan-2-yloxy)phenol

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Chemical Name:3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-((2S,3R)-3-(tert-butyldimethylsilyloxy)butan-2-yloxy)phenol
CAS No.:1352571-38-0
Molecular Formula:C₂₈H₃₈N₂O₅Si
Molecular Weight:510.706
Hs Code.:

Synonyms:3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-((2S,3R)-3-(tert-butyldimethylsilyloxy)butan-2-yloxy)phenol

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Chemical Property of 3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-((2S,3R)-3-(tert-butyldimethylsilyloxy)butan-2-yloxy)phenol

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Technology Process of 3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-((2S,3R)-3-(tert-butyldimethylsilyloxy)butan-2-yloxy)phenol

There total 6 articles about 3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-((2S,3R)-3-(tert-butyldimethylsilyloxy)butan-2-yloxy)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 480998-38-7
2-chloro-4-((4-methoxybenzyl)oxy)pyrimidine

: 1352571-37-9
2-(3-(tert-butyldimethylsilyloxy)-5-((2S,3R)-3-(tert-butyldimethylsilyloxy)butan-2-yloxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1352571-38-0
3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-((2S,3R)-3-(tert-butyldimethylsilyloxy)butan-2-yloxy)phenol

Guidance literature:: With water; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In acetonitrile; at 140 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 136-36-7
benzoate d'hydroxy-3 phenyle

: 1352571-38-0
3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-((2S,3R)-3-(tert-butyldimethylsilyloxy)butan-2-yloxy)phenol

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 90 °C

2: water; lithium hydrochloride monohydrate / tetrahydrofuran / 20 °C

3: 1H-imidazole / dichloromethane / 20 °C

4: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tert-butyl methyl ether / 16 h / 100 °C / Inert atmosphere; Microwave irradiation; Sealed tube

5: water; sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

With 1H-imidazole; lithium hydrochloride monohydrate; water; sodium carbonate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; dichloromethane; tert-butyl methyl ether; N,N-dimethyl-formamide; acetonitrile; 5: Suzuki Coupling;

Reference yield:

: 105-13-5
4-Methoxybenzyl alcohol

: 1352571-38-0
3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-((2S,3R)-3-(tert-butyldimethylsilyloxy)butan-2-yloxy)phenol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium t-butanolate / tetrahydrofuran / 1 h / Reflux

1.2: 2 h / -70 - 20 °C

2.1: water; sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

With water; sodium carbonate; sodium t-butanolate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; acetonitrile; 2.1: Suzuki Coupling;