monoacetyldapsone hydroxylamine

Base Information

• Chemical Name: monoacetyldapsone hydroxylamine
• CAS No.: 32604-86-7
• Molecular Formula: C14H14 N2 O4 S
• Molecular Weight: 306.34
• Hs Code.: 2924299090
• Mol file: 32604-86-7.mol

Synonyms:Acetanilide,4'-(N-hydroxysulfanilyl)- (8CI)

Chemical Property of monoacetyldapsone hydroxylamine

Chemical Property:

• Boiling Point: °Cat760mmHg
• PKA: 8.13±0.70(Predicted)
• Flash Point: °C
• PSA: 107.37000
• Density: 1.449g/cm³
• LogP: 4.08220
• Storage Temp.: Refrigerator
• Solubility.: Acetonitrile, DMSO

Purity/Quality:

4''-(N-Hydroxysulfanilyl)acetanilide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4''-(N-Hydroxysulfanilyl)acetanilide is an intermediate in the synthesis of Aceyl Dapsone (A168435), a metabolite of Dapsone (D193250), an antibacterial used in the treatment of dermatitis herpetiformis.

Technology Process of monoacetyldapsone hydroxylamine

There total 2 articles about monoacetyldapsone hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-[4-(4-Nitro-benzenesulfonyl)-phenyl]-acetamide (1775-37-7) → monoacetyldapsone hydroxylamine (32604-86-7)

Guidance literature:

With triethyl phosphite; platinum(IV) oxide; for 4h;

DOI:10.1016/j.bcp.2005.04.023

Reference yield:

N-[4-(4-Nitro-benzenesulfonyl)-phenyl]-acetamide (1775-37-7) → monoacetyldapsone (565-20-8) + monoacetyldapsone hydroxylamine (32604-86-7)

Guidance literature:

With palladium on activated charcoal; ethanol; Hydrogenation;

Reference yield:

monoacetyldapsone hydroxylamine (32604-86-7) → bis-[4-(N-acetyl-sulfanilyl)-phenyl]-diazene-N-oxide (50444-11-6)

Guidance literature:

With methanol; sodium hydrogencarbonate;

DOI:10.1021/ja01212a013

upstream raw materials:

N-[4-(4-Nitro-benzenesulfonyl)-phenyl]-acetamide

Downstream raw materials:

bis-[4-(N-acetyl-sulfanilyl)-phenyl]-diazene-N-oxide

Refernces